Table 2 Overall performance of HRP-2 test in asymptomatic carriers across three screening campaigns
Campaign 1 | Campaign 2 | Campaign 3 | |
|---|---|---|---|
Sensitivity, % (95% CI) | 92.4 (91.4, 93.5) | 84.0 (79.3, 88.6) | 77.8 (71.5, 84.0) |
Specificity, % (95% CI) | 74.6 (73.1, 76.1) | 87.9 (87.0, 88.7) | 95.9 (95.4, 96.4) |
Positive predictive value, % (95% CI) | 73.8 (72.2, 75.3) | 23.2 (20.3, 26.0) | 35.4 (30.5, 40.2) |
Negative predictive value, % (95% CI) | 92.7 (91.7, 93.7) | 99.2 (99.0, 99.5) | 99.3 (99.1, 99.5) |
False-positive rate | 0.25 | 0.12 | 0.04 |
False-negative rate | 0.08 | 0.16 | 0.22 |
Positive likelihood ratio | 3.64 | 6.92 | 19.01 |
Negative likelihood ratio | 0.10 | 0.18 | 0.23 |
Accuracy | 0.82 | 0.88 | 0.95 |
Kappa, % (95% CI) | 65.2 (63.2, 67.1) | 31.9 (28.3, 35.4) | 46.6 (41.4, 51.8) |