Figure 3

SUB2 immunization reduces the intensity of Plasmodium berghei infection and increases mouse survival. The parasitaemia of KLH- or SUB2-immunized mice was determined over the period of ten days after infection with P. berghei parasites (A). Each point represents the mean parasitaemia (n = 9) with error bars displaying standard errors of the mean and the asterisk denoting significance (P = 0.0042). The scatter plot displays the parasitaemia at day 10, with each point representing the parasitaemia of individual KLH- or SUB2-immunized mice (B). The red bar represents the median of each experiment with the asterisk denoting significance (P < 0.05). The survival of KLH- and SUB2-immunized mice was monitored over the course of forty days following P. berghei challenge (C). The number of surviving mice for each treatment over the duration of the experiment is displayed as a percentage of the total number of infected mice at a given time point. Statistical differences are marked by an asterisk (P = 0.0082).