Skip to main content

Advertisement

Table 2 In vivo suppression of Plasmodium berghei NK65 in mice by limonoids isolated from Carapa guianensis

From: In vitro and in vivo anti-malarial activity of limonoids isolated from the residual seed biomass from Carapa guianensis (andiroba) oil production

Dose (mg/kg/day) % Parasite inhibition Average survival time ± SD (day)
  Oral Subcutaneous Oral Subcutaneous
  5th day 7th day 5th day 7th day   
6α-acetoxygedunin (3)    
100 65.7 46.3 44.2 30.4 24 ± 3 22 ± 4
50 40.2 34.7 34.4 16.8 20 ± 3 21 ± 2
7-deacetoxy-7-oxogedunin (4)    
100 40.3 28.9 38.6 21.7 21 ± 3 22 ± 2
50 19.3 0 29.2 0 20 ± 2 21 ± 4
chloroquine diphosphate       
5 100 98 99 99 >40 >40
control 0 0 0 0 21 ± 2 21 ± 3