Table 2 In vivo suppression of Plasmodium berghei NK65 in mice by limonoids isolated from Carapa guianensis
Dose (mg/kg/day) | % Parasite inhibition | Average survival time ± SD (day) | ||||
|---|---|---|---|---|---|---|
Oral | Subcutaneous | Oral | Subcutaneous | |||
5th day | 7th day | 5th day | 7th day | |||
6α-acetoxygedunin (3) | ||||||
100 | 65.7 | 46.3 | 44.2 | 30.4 | 24 ± 3 | 22 ± 4 |
50 | 40.2 | 34.7 | 34.4 | 16.8 | 20 ± 3 | 21 ± 2 |
7-deacetoxy-7-oxogedunin (4) | ||||||
100 | 40.3 | 28.9 | 38.6 | 21.7 | 21 ± 3 | 22 ± 2 |
50 | 19.3 | 0 | 29.2 | 0 | 20 ± 2 | 21 ± 4 |
chloroquine diphosphate | ||||||
5 | 100 | 98 | 99 | 99 | >40 | >40 |
control | 0 | 0 | 0 | 0 | 21 ± 2 | 21 ± 3 |