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Table 3 Associations between variables of interest and a positive blood slide on day 1

From: Early parasite clearance following artemisinin-based combination therapy among Ugandan children with uncomplicated Plasmodium falciparum malaria

Variable Categories Risk of positive blood smear on day 1 Univariate analysis Multivariate analysis
RR* (95% CI) p-value RR(95% CI) p-value
Anti-malarial treatment DP 52.2% 1.0 (reference) - 1.0 (reference) -
  AL 67.6% 1.30 (1.13-1.49) <0.001 1.35 (1.21-1.50) <0.001
mg/kg dosing of anti-malarial ≥ median (DP) 55.0% 1.0 (reference) - Not included in final model
  < median (DP) 49.4% 0.96 (0.78-1.18) 0.68   
  ≥ median (AL) 64.3% 1.0 (reference) -   
  < median (AL) 70.7% 1.11 (0.96-1.28) 0.16   
Temperature °C < 37.0 48.2% 1.0 (reference) - 1.0 (reference) -
  37.0-37.9 59.7% 1.22 (1.03-1.44) 0.02 1.09 (0.96-1.24) 0.19
  ≥ 38.0 71.2% 1.47 (1.25-1.73) <0.001 1.17 (1.04-1.33) 0.01
Parasite density per μL < 4,000 21.3% 1.0 (reference) - 1.0 (reference) -
  4,000-20,000 57.4% 2.64 (1.93-3.63) <0.001 2.62 (1.90-3.62) <0.001
  > 20,000 73.5% 3.39 (2.51-4.59) <0.001 3.31 (2.44-4.49) <0.001
Haemoglobin g/dL ≥ 10 60.0% 1.0 (reference) - Not included in final model
  < 10 64.0% 1.08 (0.92-1.26) 0.33   
HIV status Negative 60.5% 1.0 (reference) - Not included in final model
  Positive 58.3% 0.97 (0.72-1.31) 0.84   
Episode number 1-2 59.9% 1.0 (reference)   Not included in final model
  3-4 57.1% 0.94 (0.82-1.09) 0.42   
  ≥ 5 65.0% 1.02 (0.90-1.17) 0.74   
  1. *Relative risk using generalized estimating equations with adjustment for repeated measures in the same patient.
  2. Relative risk using generalised estimating equations with adjustment for repeated measures in the same patient, age and gender.