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Figure 7 | Malaria Journal

Figure 7

From: A novel approach for the discovery of chemically diverse anti-malarial compounds targeting the Plasmodium falciparum Coenzyme A synthesis pathway

Figure 7

Coenzyme A supplementation reduces the cytotoxic effect in a dose respondent manner. A: For both compounds Amb4317088 and MMV000304 the observed cytotoxic effect was reduced upon supplementation of CoA. The optimal CoA concentration was determined for each CoA batch and was fixed within each experiment. Graphs represent n = 2 in duplicate point each; error bars indicate +/- standard error of mean (SEM). B: The cytotoxic effect of the control compound puromycin is not reduced by CoA addition, whereas the cytotoxic effect of panthenol is counteracted by CoA. Curves show n = 2 in duplicate point each; error bars indicate +/- standard error of mean (SEM).

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Malaria Journal

ISSN: 1475-2875

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