|
Group
|
Day of treatment
|
Parasite density (geometric mean)
|
PRR
|
Time to 50 % parasite density (days)
|
Time to 90 % parasite density (days)
|
|---|
|
SCD
|
Day 0
|
1197
|
-
| |
-
|
|
Day 1
|
788
|
1.52
|
2
|
5
|
|
Day 2
|
599
|
1.99
| | |
|
Day 3
|
226
|
5.28
| | |
|
HbAA
|
Day 0
|
11,774
|
-
| | |
|
Day 1
|
2,811
|
4.18
|
0.6
|
1.6
|
|
Day 2
|
118
|
99.23
| | |
|
Day 3
|
32
|
367.95
| | |
|
SCD-AA
|
Day 0
|
1,012
|
-
| | |
|
Day 1
|
684
|
1.47
|
2.7
|
3
|
|
Day 2
|
2,135
|
0.47
| | |
|
Day 3
|
64
|
15.81
| | |
|
SCD-AL
|
Day 0
|
1,408
|
-
| | |
|
Day 1
|
869
|
1.62
|
1.25
|
7
|
|
Day 2
|
228
|
6.15
| | |
|
Day 3
|
2840
|
0.49
| | |
- SCD = sickle cell disease, HbAA = non-SCD, SCD-AA = SCD subjects treated with artesunate-amodiaquine, SCD-AL = SCD subjects treated with artemether-lumefantrine.
