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Table 1 Iron absorption, iron and inflammation parameters among Malawian toddlers after anti-malarial treatment

From: The effect of timing of iron supplementation on iron absorption and haemoglobin in post-malaria anaemia: a longitudinal stable isotope study in Malawian toddlers

  

1. visit

2. visit

3. visit

4. visit

5. visit

6. visit

7. visit

  

0 weeks

2 weeks

4 weeks

6 weeks

8 weeks

10 weeks

12 weeks

Absorption (geometric mean%, 95% CI)

     
 

A

9.0a (7.4-11.0)

8.8a,c (6.5-11.8)

N.A.

N.A.

3.1b (2.1-4.7)

N.A.

N.A.

 

B

N.A.

11.5a (10.0-13.1)

5.7c,d (3.9-8.5)

N.A.

N.A.

3.9b,d (2.4-6.4)

N.A.

Haemoglobin concentration (g/L, mean, ±SD)

 

A

84a ± 7

104b ± 9

113d ± 10

116d ± 9

111c,d ± 12

114d ± 13

N.A.

 

B*

80a ± 9

100b ± 9

106c ± 12

108c ± 11

109c,d ± 13

114d ± 14

111c,d ± 12

Plasma ferritin (μg/L, median, 25th 75th)

     
 

A

189a (142–263)

57b,c,d (36–94)

56b,c,d (38–84)

49b,c,d (40–90)

49b,c (34–64)

45b,c (30–69)

N.A.

 

B

N.A.

39c (14–52)

46c,b (28–102)

57b,d (34–88)

66b,d (37–99)

77b,d (45–169)

102d (56–163)

C-reactive protein (mg/L, median, 25th 75th)

     
 

A

36.7a (24.2-44.8)

1.6b (0.5-3.3)

3.6b (0.5-10.3)

1.6b (0.8-5.1)

2.1b (0.8-9.1)

1.4b (0.7-5.0)

N.A.

 

B

N.A.

2.5b (1.3-7.3)

2.2b (0.6-4.4)

4.3b (1.8-10.9)

3.3b (0.8-7.9)

1.1b (0.6-5.9)

4.3b (2.9-8.5)

AGP (g/L, median, 25th 75th)

      
 

A

1.86a (1.56-1.98)

1.05b (0.88-1.52)

0.98b (0.88-1.27)

1.07b (0.69-1.23)

1.09b (0.83-1.38)

1.02b (0.66-1.25)

N.A.

 

B

N.A.

1.25b (0.96-1.55)

1.06b,c (0.70-1.37)

1.07b,c(0.84-1.6)

1.01b,c (0.80-1.37)

0.86c (0.69-1.14)

1.10b,c (0.89-1.33)

  1. Malawian toddlers presenting with post-malarial anaemia were supplemented with 30 mg iron for 8 weeks, either directly after malaria treatment (group A, n = 24) or starting with a 2-week delay (group B, n = 24). Children received a dose of a stable iron isotope (57Fe) at three occasions, i.e. group A at week 0, 2 and 8 and group B at week 2, 4 and 10. Iron and inflammation parameters are stratified by iron supplementation group and visits. Abbreviations: AGP, α1-acid glycoprotein; CI, confidence interval; N.A., not applicable; SD, standard deviation.
  2. a,b,c,dIf two mean/median values within one parameter carry the same superscript letter, they are not significantly different, i.e. P > 0.05. Different letters indicate significant differences (P < 0.05) within and between groups A and B for iron absorption, iron and inflammation parameters were assessed with random effect models.
  3. *Haemoglobin concentration measured with HemoCue 201 in group B at visit 1.