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Table 3 Summary of univariate and multivariate Poisson regression analysis of relationship between PF13 and MSP1 antibody response with incidence rate of malaria attacks in Ndiop

From: Comparative analysis of IgG responses to Plasmodium falciparum MSP1p19 and PF13-DBL1α1 using ELISA and a magnetic bead-based duplex assay (MAGPIX®-Luminex) in a Senegalese meso-endemic community

 

Univariate individual antigen analysis

PF13 and MSP1p19 adjusted model

PF13 and MSP1p19 model adjusted for age

 

OR

95% CI

P

OR

95% CI

P

OR

95% CI

P

ELISA OD

        

PF13

0.70

[0.6-0.9]

<0.01

0.89

[0.74-1.1]

0.25

0.88

[0.7-1.1]

0.19

MSP1

0.46

[0.37-0.59]

<0.01

0.49

[0.38-0.62]

<0.001

0.81

[0.62-1.1]

0.12

MFI

         

PF13

0.99

[0.99-0.99]

0.02

0.99

[0.99-1.0]

0.12

0.99

[0.99-1.0]

0.06

MSP1

0.99

[0.99-0.99]

<0.01

0.99

[0.99-0.99]

<0.01

0.99

[0.99-1.0]

0.58

OD ratio

        

PF13

0.96

[0.94-0.98]

<0.01

0.98

[0.96-1.0]

0.06

0.98

[0.96-1.0]

0.08

MSP1

0.88

[0.85-0.92]

<0.01

0.89

[0.86-0.93]

<0.001

0.97

[0.93-1.0]

0.13

MFI ratio

        

PF13

0.98

[0.97-0.99]

0.02

0.99

[0.9-1.0]

0.11

0.98

[0.97-1.0]

0.06

MSP1

0.95

[0.93-0.97]

<0.01

0.95

[0.93-0.98]

<0.01

0.99

[0.96-1.0]

0.52

Dichotomized antibody response according to OD ratio threshold

    

PF13 positivity

0.79

[0.60-1.04]

0.10

0.98

[0.74-1.30]

0.90

1.2

[0.86-1.6]

0.30

MSP1 positivity

0.44

[0.34-0.57]

<0.01

0.44

[0.33-0.57]

<0.001

0.71

[0.53-0.93]

0.01

Dichotomized antibody response according to MFI Ratio threshold

    

PFf13 positivity

0.83

[0.63-1.1]

0.17

1.01

[0.7-1.4]

0.91

1.08

[081–1.45]

0.57

MSP1 positivity

0.61

[0.47-0.79]

<0.01

0.61

[0.4-0.8]

<0.001

0.89

[0.67-1.18]

0.43

Dichotomized antibody response according with ROC threshold

    

PF13 positivity

0.70

[0.5-0.9]

0.03

0.89

[0.7-1.2]

0.48

1.1

[0.8-1.5]

0.48

MSP1 positivity

0.78

[0.60-1.02]

0.07

0.82

[0.6-1.1]

0.21

1.05

[0.78-1.4]

0.75