Table 2 Anti-malarial activity of tigecycline in Plasmodium berghei mouse malaria model, alone and in combination with chloroquine
Treatment | Dose(mg/kg) | Parasitaemia suppression (%)1 | Cure2 | MST(days)3 |
|---|---|---|---|---|
Vehicle | - | - | 0/5 | 12.8±2.3 |
CQ | 11.1 | >99.99 | 0/5 | >28 |
33.3 | >99.99 | 0/5 | >28 | |
100 | >99.99 | 0/5 | >28 | |
TG | 3.7 | 77.7 ± 9.5 | 0/5 | 15.2 ± 2.9 |
11.1 | 93.6 ± 2.7 | 0/5 | >28 | |
33.3 | 97.3 ± 1.2 | 0/5 | >28 | |
100 | 97.6 ± 0.9 | 0/5 | >28 | |
TG (DD)* | 3.7 | 91.80 ± 3.7 | 0/5 | 16.0 ± 3.7 |
11.1 | 96.3 ± 1.7 | 0/5 | >28 | |
33.3 | 98.7 ± 0.9 | 0/5 | >28 | |
100 | 98.1 ± 0.5 | 0/5 | >28 | |
CQ + TG | 33.3 + 3.7 | >99.99 | 1/5 | >28 |
33.3 + 11.1 | >99.99 | 3/5 | >28 | |
33.3 + 33.3 | >99.99 | 5/5 | >28 | |
33.3 + 100 | >99.99 | 5/5 | >28 |