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Table 2 Clinical and prognostic features of microscopy negative (N = 10) and microscopy positive (N = 169) patients enrolled in clinical trial with all three bands positive on RDT 1

From: Use of a three-band HRP2/pLDH combination rapid diagnostic test increases diagnostic specificity for falciparum malaria in Ugandan children

  Microscopy negative (N = 10) Microscopy positive (N = 169) P value
Parasite density (geometric mean, range) 0 17,700 (80–696,000) -
Duration of fever prior to presentation (days), median (IQR) 3.5 (2.0-6.0) 3.0 (2.0-4.0) 0.78
Prostration, n/N (%) 8/10 (80) 155/169 (92) 0.22
Coma, n/N (%) 5/10 (50) 101/169 (60) 0.74
Convulsions, n/N (%) 8/10 (80) 135/169 (80) 1.0
BCS, median (IQR) 3 (2–4) 2 (2–3) 0.33
Deep breathing, n/N (%) 2/10 (20) 84/169 (50) 0.10
LODS2, median (IQR) 2 (1–2) 2 (1.5-3) 0.067
pH <7.353, n/N (%) 2/9 (22) 40/137 (29) 1.0
Lactate > 5 mmol/L3, n/N (%) 2/10 (20) 57/161 (35) 0.50
Base deficit > 8 mmol/L3, n/N (%) 4/9 (44) 65/137 (47) 1.0
  1. 1One additional patient was diagnosed with P. ovale based on microscopy, but PCR identified P. falciparum mono-infection.
  2. 2Lambaréné Organ Dysfunction Score.
  3. 3pH < 7.35[20], lactate > 5 mmol/L and base deficit > 8 mmol/L[21] (lactic acidosis) have been identified as markers of poor prognosis in severe malaria.