Table 3 Treatment outcome stratified by site
Treatment outcome stratified by locality | Artesunate/Amodiaquine | Artemether/Lumefantrine | p value |
|---|---|---|---|
ABIDJAN (130 patients) | 65 | 65 | |
ITT analysis | |||
Crude failure rate at day 42 | 3/65 (4.61%) | 00/65 (00%) | 0.07 |
Crude cure rate at day 42 | 62/65 (95.4%) | 65/65 (00%) | 0.07 |
PCR adjusted failure rate at day 42 | 1/65 (1.5%) | 00/65 (00%) | 0.31 |
PCR adjusted ACPR at day 42 | 64/65 (98.5%) | 65/65 (100%) | 0,31 |
% difference | 1,5 [-1 ; 4] | ||
PP analysis | |||
Crude failure rate at day 42 | 2/64 (3.1%) | 00/65 (00%) | 0.31 |
Crude cure rate at day 42 | 62/64 (96.9%) | 65/65 (00%) | 0,31 |
PCR adjusted failure rate at day 42 | 00/64 (00%) | 00/65 (00%) | 1 |
PCR adjusted ACPR at day 42 | 64/64 (100%) | 65/65 (100%) | 1 |
% difference | 0 | ||
KORHOGO (128 patients) | 64 | 64 | |
ITT analysis | |||
Crude failure rate at day 42 | 03/64 (4.7%) | 03/64 (4.7%) | 1 |
Crude cure rate at day 42 | 61/64 (95.3%) | 61/64 (95.3%) | 1 |
PCR adjusted failure rate at day 42 | 00/64 (00%) | 00/64 (00%) | 1 |
PCR adjusted ACPR at day 42 | 61/64 (95.3%) | 64/64 (100%) | 0.07 |
% difference | 4,7[0 ; 9] | ||
PP analysis | |||
Crude failure rate at day 42 | 00/61 (00%) | 03/64 (4.7%) | 0.07 |
Crude cure rate at day 42 | 61/61 (100%) | 61/64 (95.3%) | 0.07 |
PCR adjusted failure rate at day 42 | 00/61 (00%) | 00/64 (00%) | 1 |
PCR adjusted ACPR at day 42 | 61/61 (100%) | 64/64 (100%) | 1 |
% difference | 0 | ||
MAN (125 patients) | 59 | 66 | |
ITT analysis | |||
Crude failure rate at day 42 | 02/59 (3.4%) | 4/66 (6%) | 0.47 |
Crude cure rate at day 42 | 55/59 (93.2%) | 62/66 (94%) | 0.47 |
PCR adjusted failure rate at day 42 | 02/59 (3.4%) | 02/66 (3%) | 0.90 |
PCR adjusted ACPR at day 42 | 57/59 (96.6%) | 64/66 (97%) | 0,90 |
% difference | 0,4[-5 ; 6] | ||
PP analysis | |||
Crude failure rate at day 42 | 02/57 (3.5%) | 02/64 (3.1%) | 0.90 |
Crude cure rate at day 42 | 55/57 (96.5%) | 62/64 (96.9%) | 0.90 |
PCR adjusted failure rate at day 42 | 00/57 (00%) | 00/64 (00%) | 1 |
PCR adjusted ACPR at day 42 | 57/57 (100%) | 64/64 (100%) | 1 |
% difference | 0 | ||