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Table 5 Protective efficacy (and confidence interval) for mefloquine and tafenoquine for malaria prophylaxis in non-immune Australian soldiers deployed to Timor Leste for six months in 2000/2001 (an attack rate of 7.88% was assumed)

From: A retrospective analysis of the protective efficacy of tafenoquine and mefloquine as prophylactic anti-malarials in non-immune individuals during deployment to a malaria-endemic area

  Results during the prophylactic phase of Study 033 Protective efficacy (PE) during prophylactic phase of Study 033     
Drug ITT Population Malaria cases Subjects lost to follow-up Drug attack rate (%) (95% CI)* PE (%)** 95% CI***
Mefloquine 161 0 0 0 (0, 0.549) 100 79 - 100
Tafenoquine 490 0 0 0 (0, 1.653) 100 93 – 100
  1. *Confidence interval (CI) for the attack rate (AR) is based on Wilson (score) method for proportions. In the special case when AR = 0 (0/n), the upper limit corresponds to a one-sided upper 95% limit. For AR = 0, the lower limit is set to zero.
  2. **PE = [1 – drug AR/0.0788)]100. For zero cases, PE = 100%.
  3. ***95% CI for protective efficacy (PE) obtained from corresponding limits for the drug attack rates. The lower limit for PE = [1- AR upper limit/0.0788] x 100. The upper AR limits for tafenoquine (0/490) and mefloquine (0/161) are 0.549% and 1.653%. For PE = 100%, the upper limit is set to 100%.