Figure 3

Comparative kinetics of formation of (A) 2-hydroxyprimaquine; (B) 3-hydroxyprimaquine; (C) 4-hydroxyprimaquine and (D) 5-hydroxyprimaquine (expressed as the orthoquinone, relative to primaquine calibration) on metabolism of primaquine (racemate and individual enantiomers) by human CYP2D6. Each point represents mean value ± S.D. (n = 4).