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Table 5 McDonald-Kreitman test for evaluating the action of natural selection

From: Low genetic diversity and functional constraint in loci encoding Plasmodium vivax P12 and P38 proteins in the Colombian population

  P. vivax/P. cynomolgi P. vivax/P. knowlesi
Worldwide isolates
   Fixed Polymorphic PN/PS> DN/DSp-values Fixed Polymorphic PN/PS> DN/DSp-values
pv12 Non-synonymous substitutions 78.66 4 0.002 93.86 4 0.000
Synonymous substitutions 190.23 0 340.47 0  
pv38 Non-synonymous substitutions 85.90 6 0.004 85.14 6 0.003
  Synonymous substitutions 257.31 3   265.94 3  
Colombian population
pv12 Non-synonymous substitutions 93.05 1 0.146 115.54 1 0.083
Synonymous substitutions 197.20 0 347.80 0  
pv38 Non-synonymous substitutions 89.22 5 0.023 88.50 5 0.016
  Synonymous substitutions 248.66 3   264.90 3  
  1. The McDonald-Kreitman test was done using sequences obtained from databases (worldwide isolates) together with Colombian ones, and just with those obtained in the Colombian population. The interspecies divergence data were obtained from comparing Plasmodium vivax sequences with two related species: Plasmodium cynomolgi and Plasmodium knowlesi. Significant values are shown in italics.