Skip to main content

Table 5 McDonald-Kreitman test for evaluating the action of natural selection

From: Low genetic diversity and functional constraint in loci encoding Plasmodium vivax P12 and P38 proteins in the Colombian population

 

P. vivax/P. cynomolgi

P. vivax/P. knowlesi

Worldwide isolates

  

Fixed

Polymorphic

PN/PS> DN/DSp-values

Fixed

Polymorphic

PN/PS> DN/DSp-values

pv12

Non-synonymous substitutions

78.66

4

0.002

93.86

4

0.000

Synonymous substitutions

190.23

0

340.47

0

 

pv38

Non-synonymous substitutions

85.90

6

0.004

85.14

6

0.003

 

Synonymous substitutions

257.31

3

 

265.94

3

 

Colombian population

pv12

Non-synonymous substitutions

93.05

1

0.146

115.54

1

0.083

Synonymous substitutions

197.20

0

347.80

0

 

pv38

Non-synonymous substitutions

89.22

5

0.023

88.50

5

0.016

 

Synonymous substitutions

248.66

3

 

264.90

3

 
  1. The McDonald-Kreitman test was done using sequences obtained from databases (worldwide isolates) together with Colombian ones, and just with those obtained in the Colombian population. The interspecies divergence data were obtained from comparing Plasmodium vivax sequences with two related species: Plasmodium cynomolgi and Plasmodium knowlesi. Significant values are shown in italics.