Plasmodium vivax and Plasmodium falciparum ex vivo susceptibility to anti-malarials and gene characterization in Rondônia, West Amazon, Brazil

Table 3 Overall ex - vivo sensitivity of Brazilian isolates for each drug, according to the species tested, and for laboratory P . falciparum (W2 clone) line, chloroquine resistant

Drug	P. falciparum					P. vivax Clinical field isolates
Drug	W2	Fc27*	African	Clinical field isolates		P. vivax Clinical field isolates
	IC₅₀(nM)			n	Median IC₅₀(nM)**	n	Median IC₅₀(nM)
Chloroquine	178	39	19	9	70 (0.19-223; 80)		32 (3–69; 64)
Artesunate	18	16	1.5	9	1.3 (0.26-5.8; 2.82)	32	21 (0.08-137; 17.4)
Mefloquine	19	11	46	9	21 (1.19-63; 80)		57 (5.0-113; 82)

*Date from Marfurt et al.[28, 29]. **The numbers inside of the parenthesis means: lowest IC₅₀, higher IC₅₀ and interquartile range.

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