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Table 3 Overall ex - vivo sensitivity of Brazilian isolates for each drug, according to the species tested, and for laboratory P . falciparum (W2 clone) line, chloroquine resistant

From: Plasmodium vivax and Plasmodium falciparum ex vivo susceptibility to anti-malarials and gene characterization in Rondônia, West Amazon, Brazil

Drug P. falciparum P. vivax Clinical field isolates
W2 Fc27* African Clinical field isolates
  IC50(nM) n Median IC50(nM)** n Median IC50(nM)
Chloroquine 178 39 19 9 70 (0.19-223; 80)   32 (3–69; 64)
Artesunate 18 16 1.5 9 1.3 (0.26-5.8; 2.82) 32 21 (0.08-137; 17.4)
Mefloquine 19 11 46 9 21 (1.19-63; 80)   57 (5.0-113; 82)
  1. *Date from Marfurt et al.[28, 29]. **The numbers inside of the parenthesis means: lowest IC50, higher IC50 and interquartile range.