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Table 4 Logistic regression analysis of variables predicting renal replacement therapy in patients with severe malaria

From: Correlation of biomarkers for parasite burden and immune activation with acute kidney injury in severe falciparum malaria

 

Univariate analysis

Multivariate model (R2 = 0.27)

Variable

OR (95% CI)b

P

OR (95% CI)b

P

suPAR

1.07 (1.04-1.11)

<0.001

1.07 (1.03-1.12)

0.002

Pf HRP21/2

1.03 (1.02-1.05)

<0.001

1.02 (1.00-1.04)

0.026

suPAR1/2 x Pf HRP21/2

1.01 (1.00-1.01)

<0.001

---

---

SBP

1.01 (0.99-1.03)

0.522

---

---

Age

1.02 (0.99-1.05)

0.123

1.05 (1.01-1.10)

0.010

  1. bOdds ratios (OR) with 95% CIs were determined for renal replacement therapy (RRT) associated with 1-U changes in the independent variables. Significant variables are shown in bold. Pf HRP2 was square root transformed to normalize skewed data. Significant in bold.
  2. OR = odds ratio; CI = confidence intervals; uNGAL/Ucr = urine neutrophil-associated gelatinase lipocalin corrected for urine creatinine; suPAR = soluble urokinase plasminogen activator receptor; Pf HRP2 = P. falciparum histidine rich protein 2; SBP = systolic blood pressure.
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Malaria Journal

ISSN: 1475-2875

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