Skip to content

Advertisement

  • Oral presentation
  • Open Access

Dynamics of P. vivax clones in a cohort of children with or without primaquine treatment at baseline

  • 1, 2,
  • 3, 4,
  • 1, 2,
  • 3, 5,
  • 4,
  • 1, 2,
  • 4,
  • 1, 2,
  • 3, 6 and
  • 1, 2
Malaria Journal201413 (Suppl 1) :O24

https://doi.org/10.1186/1475-2875-13-S1-O24

  • Published:

Keywords

  • Placebo
  • Blood Sample
  • Infectious Disease
  • Lower Risk
  • Placebo Recipient

P. vivax was detected by PCR in 45% of children aged 5-10 years from our study area in Papua New Guinea (PNG). 504 children were randomized into 2 arms according to Primaquine (PQ) treatment or not at baseline and actively and passively followed for 9 months. We genotyped all P. vivax infections, the majority of these being multi-clone infections. All blood samples positive for P. vivax by qPCR were tested for gametocyte carriage by targeting pvs25 transcripts. Primaquine reduced the risk of P. vivax infections by 80%. The multiplicity of infection and the density of asexual P. vivax stages were not significantly different in both treatment arms. The number of new clones (force of blood-stage infection) was 2.38 ± 0.17 per person per year-at-risk in the PQ-arm compared to 8.04 ± 0.41 in the Placebo arm (P < 0.05). The duration of infections did not differ between the treatment arms, with 73 days [95% CI: 33-849] and 68 days [95% CI: 40-247] in the PQ or Placebo arm, respectively. Detectability of P. vivax clones was low with 0.26 ± 0.06 and 0.24 ± 0.04 in the PQ and Placebo arms. PQ-treated children had a 75% lower risk of carrying gametocytes compared to Placebo recipients. P. vivax positive children in both arms were equally likely to show gametocyte positivity. We conclude that P. vivax relapses contribute significantly to the high burden of P. vivax infection and transmission in PNG. All other infection dynamics parameters were consistent between treatment arms and apparent relapses behave like new infections.

Authors’ Affiliations

(1)
Swiss Tropical and Public Health Institute, Basel, Switzerland
(2)
University of Basel, Basel, Switzerland
(3)
Walter and Eliza Hall Institute, Parkville, Australia
(4)
PNG Institute of Medical Research, Madang & Maprik, Papua New Guinea
(5)
Department of Medical Biology, University of Melbourne, Victoria, Australia
(6)
Centre de Recerca en Salut Internacional de Barcelona (CRESIB), Barcelona, Spain

Copyright

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Please note that comments may be removed without notice if they are flagged by another user or do not comply with our community guidelines.

Advertisement