Volume 13 Supplement 1

Challenges in malaria research: Core science and innovation

Open Access

Malnutrition influences tumor necrotic factor-alpha (TNF-α) response among Plasmodium falciparum (Pf) malaria patients in Nigeria

  • Olusola Ajibaye1, 2,
  • Akiniyi Osuntoki2,
  • Bassey Orok1, 2,
  • Bamidele Iwalokun1,
  • Nneka Egbuna1,
  • Yetunde Olukosi1,
  • Olugbenga Aina1,
  • Hilary Okoh1,
  • Chimere Agomo1,
  • Vera Enya1,
  • Oladayo Faneye3,
  • Samuel Akindele1,
  • Olutope Akinnibosun1,
  • Kolapo Oyebola1,
  • Sunday Adenekan2 and
  • Albert Ebuehi2
Malaria Journal201413(Suppl 1):P3

https://doi.org/10.1186/1475-2875-13-S1-P3

Published: 22 September 2014

Background

In malaria endemic regions, malnutrition has also been reported to be a public health problem. Considering that the pattern of host cytokines-mediated innate immunity is critical in determining malaria outcomes-understanding the impact of malnutrition on innate immune response in Plasmodium falciparum (Pf)-infected patients may be helpful for malaria control. This study aims to determine nutritional status and evaluate the influence of malnutrition on the immune response of infected patients in Lagos, Nigeria.

Methods

Volunteers (1,838) with a history of fever or axilliary temperature ≥37°C were screened microscopically for Pf in a cross-sectional study at Ijede General Hospital, Lagos, Nigeria. Body mass index (BMI) of patients was determined and used as a measure of nutritional status. A BMI of <18.5 kg/m2 was taken as an index of malnutrition while participants <20 years were further classified based on Z-scores (Z-Scores ≤-2) into stunted, wasted or underweight. TNF-α, interleukin-1β and interleukin-12 were determined by ELISA and haematological parameters (Full blood count) were measured using Beckman Coulter Closed Tube Automated Hematology System. Statistical analysis was done using SPSS Version 17. The study protocol was approved by NIMR Institutional Review Board.

Results

A total of 364 patients comprising of 47% males and 53% females with a median age of 10 years were recruited for which average BMI was 18.19+6.10. Malaria prevalence was 20.85% and malnutrition rate 62.5%. In the <20 years group, 24 (16.7%) were stunted, 30 (20.8%) were underweight and 48 (33.3%) were wasted. TNF-α was associated with age, observed to be higher in <5 years (P = 0.001). Mean levels of TNF-α were significantly higher in malnourished patients P < 0.05.

Conclusions

This study suggests that nutritional status modulates malaria outcomes and pattern of progression in all ages with an inference of high malnutrition rate in the studied population.

Authors’ Affiliations

(1)
Nigerian Institute of Medical Research
(2)
University of Lagos
(3)
University of Ibadan

Copyright

© Ajibaye et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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