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Table 2 PK parameters of NP046

From: Efficacy and pharmacokinetic evaluation of a novel anti-malarial compound (NP046) in a mouse model

PK parameter Oral IV
Nominal Dose (mg/kg) 50 10 5
Apparent t 1/2 (h) 4.4 ± 0.60 3.1 ± 0.46 3.2 ± 0.35
Blood CL total (mL/min/kg) 62.2 ± 3.0
Vd (L/Kg) 16.9 ± 1.3
C max (μM) 0.47 ± 0.10 0.13 ± 0.06
T max (min) 30 48
AUC 0 - ∞ (min. μmol/L) 80 ± 8.8 30 ± 14.7 248 ± 12.6
Bioavailability (%) 3.2 ± 0.47 6.0 ± 2.9 N/A
  1. Results are mean of n = 5 ± S.E.M.