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Table 1 Dose-response effects of mefloquine on elevation of cytosolic calcium levels induced via liberation of the ER store.

From: The acute neurotoxicity of mefloquine may be mediated through a disruption of calcium homeostasis and ER function in vitro

Concentration in μM (# of experiments) Relative increase in cytosolic CA2+ due to ER calcium release (range) Magnitude of effect relative to 200 μM mefloquine (%)
DMSO (4) 1.0 (1.0–1.0) 0
2 (4) 1.0 (1.0–1.2) 2.4
10 (4) 1.1 (1.0–1.2) 3.6
30 (5) 1.5 (1.2–1.7) 30
60 (4) 1.9 (1.8–2.6) 53
80 (4) 2.5 (2.1–2.9) 74
200 (4) 3.2 (2.6–4.1) 100