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Table 3 Accumulation of mefloquine in the brain.

From: The acute neurotoxicity of mefloquine may be mediated through a disruption of calcium homeostasis and ER function in vitro

Animal/Case Mefloquine Brain Concentration (μM equivalent) Mefloquine Plasma Concentration (μM) Brain/plasma ratio Reference
Rats (50 mg/kg daily) 90 7.2 12.5 [23]
Human case 1 (p.m.) 52 1.7 30.1 [24]
Human case 2 (p.m.) 32–51 ? - [24]
Mean of three human cases 3–5 (p.m.) 27* Postmortem redistribution? - [25]
  1. * Data calculated from literature data on basis of the free-base mefloquine molecular weight of 378.4.