From: The acute neurotoxicity of mefloquine may be mediated through a disruption of calcium homeostasis and ER function in vitro
Animal/Case
Mefloquine Brain Concentration (μM equivalent)
Mefloquine Plasma Concentration (μM)
Brain/plasma ratio
Reference
Rats (50 mg/kg daily)
90
7.2
12.5
[23]
Human case 1 (p.m.)
52
1.7
30.1
[24]
Human case 2 (p.m.)
32–51
?
-
Mean of three human cases 3–5 (p.m.)
27*
Postmortem redistribution?
[25]
