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Table 3 Frequencies and geometric mean levels of IL-10 responses to PHA, LSA-1 and MSP-1 peptides by presence of P. falciparum parasitemia

From: Interferon-gamma responses to Plasmodium falciparum liver-stage antigen-1 and merozoite-surface protein-1 increase with age in children in a malaria holoendemic area of western Kenya

Condition PHA MSP-1 (aa 20–39) LSA-1, T3
Blood smear No. pos./Tot. (%)a Geo. mean (range)b No. pos./Tot (%) Geo. mean (range) No. pos./Tot (%) Geo. mean (range)
P. falciparum positive 25/36 (69.4) 175.5 (0–847.4) 5/32 (15.6) 23.7 (0–445.9) 2/31 (6.5) 6.9 (0–125.2)
P. falciparum negative 11/12 (91.7) 330.1 (8.4–1247.4) 2/9 (22.2) 14.7 (0–67.7) 1/8 (12.5) 16.6 (0–125.2)
P NSc NSd NS NS NS NS
  1. a A positive response was defined as any response ≥ 20 pg/ml above that of unstimulated cell culture supernatants and had a positive or negative blood smear. b Geometric mean cytokine levels in pg/ml. c NS= not significant. P < 0.05 considered significant, as determined by χ2 test for trend across age groups. d P < 0.05 was considered significant as determined by analysis of variance of log-transformed values across age groups.