Figure 1

Log asexual parasite densities of the resistant clone R over time in untreated (a) and drug-treated (b) mice infected with R alone or a mixture of R+S clones, and total numbers of R parasites produced over the acute (c) and chronic phases (d). All data points (mean ± 1 s.e.m.) are based on 5 replicate mice, except for mixed infections in untreated mice in (a) (4 mice on day 11 and 3 mice from day 12 onwards) and (c) and (d) (3 mice). As the limit of detection was 100 parasites per μl blood, y-axes in (a) and (b) start at 2.