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Table 1 Comparison of studies during which a rebound effect was observed upon termination of drug treatment. Studies are in the order they are cited in the text.

From: The promise and potential challenges of intermittent preventive treatment for malaria in infants (IPTi)

Drug used (country) Ages of study group Duration of treatment Duration of post-intervention follow-up Effect on malaria morbidity Rebound effect Reference
P-D1 (Tanzania) 2 mo. at start of study Weekly for one year One year after termination of treatment Reduced incidence of clinical malaria by 40% during treatment period 80% higher incidence of clinical episodes in treated group during the year following termination of treatment [17]
P-D (The Gambia) 3 mo. at start of study Every 2 weeks for maximum of 5 years 5 years 65% reduction in malaria episodes after 3 years of chemoprophylaxis 52% more cases in treated group during the year following termination of treatment [18, 22]
SP2 + artesunate (The Gambia) Entire villages, all ages MDA3 1 dose 20 weeks Reduced rate of malaria attacks in children <11 yr by 60% Rate of clinical malaria was 69% higher in treated groups 3 months after treatment [25]
SP (Mali) 3 mo. to 20 years MDA 1 dose 24 weeks Reduced incidence of first malaria episode from 26% to 3% during first month Incidence of first malaria episodes in treated group rose to 42% compared to 17% (untreated group) during the third month after treatment [26]
  1. 1P-D: pyrimethamine-dapsone
  2. 2SP: sulfadoxine-pyrimethamine
  3. 3MDA: mass drug administration