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Table 1 Comparison of studies during which a rebound effect was observed upon termination of drug treatment. Studies are in the order they are cited in the text.

From: The promise and potential challenges of intermittent preventive treatment for malaria in infants (IPTi)

Drug used (country)

Ages of study group

Duration of treatment

Duration of post-intervention follow-up

Effect on malaria morbidity

Rebound effect


P-D1 (Tanzania)

2 mo. at start of study

Weekly for one year

One year after termination of treatment

Reduced incidence of clinical malaria by 40% during treatment period

80% higher incidence of clinical episodes in treated group during the year following termination of treatment


P-D (The Gambia)

3 mo. at start of study

Every 2 weeks for maximum of 5 years

5 years

65% reduction in malaria episodes after 3 years of chemoprophylaxis

52% more cases in treated group during the year following termination of treatment

[18, 22]

SP2 + artesunate (The Gambia)

Entire villages, all ages

MDA3 1 dose

20 weeks

Reduced rate of malaria attacks in children <11 yr by 60%

Rate of clinical malaria was 69% higher in treated groups 3 months after treatment


SP (Mali)

3 mo. to 20 years

MDA 1 dose

24 weeks

Reduced incidence of first malaria episode from 26% to 3% during first month

Incidence of first malaria episodes in treated group rose to 42% compared to 17% (untreated group) during the third month after treatment


  1. 1P-D: pyrimethamine-dapsone
  2. 2SP: sulfadoxine-pyrimethamine
  3. 3MDA: mass drug administration