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Table 1 Associations between dhfr and crt mutations in 126 Ghanaian children with uncomplicated malaria

From: Concurrence of Plasmodium falciparum dhfr and crt mutations in northern Ghana

dhfr mutation Prevalence of crt T76 mutation (%) Odds ratio (95%CI) of crt T76 being present
   Unadjusted P Adjusted for CQ in blood* P
51
   absent 67.9 (38/56) 1   1  
   present 90.0 (63/70) 4.3 (1.5–12.5) 0.002 5.0 (1.8–13.8) 0.002
59
   absent 63.6 (28/44) 1   1  
   present 89.0 (73/82) 4.6 (1.7–13.0) 0.0007 4.4 (1.7–11.4) 0.002
108
   absent 65.7 (23/35) 1   1  
   present 85.7 (78/91) 3.1 (1.2–8.6) 0.01 3.2 (1.2–8.2) 0.02
triple
   absent 68.7 (46/67) 1   1  
   present 93.2 (55/59) 6.3 (1.9–26.6) 0.0006 7.0 (2.2–22.5) 0.001
  1. dhfr, dihydrofolate reductase gene, crt, chloroquine resistance transporter gene; 95%CI, 95% confidence interval; CQ, chloroquine; *, Potential confounders were tested for in logistic regression models including age, sex, parasite density, dhps alleles, and axillary temperature. Adjusted odds ratios include the presence of chloroquine in blood as the only factor found to be associated (univariate odds ratio, 3.2; 95%CI, 1.2–8.6; P = 0.01).
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