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Table 3 Changes of laboratory values between baseline and study day 3 (haemoglobin, Hb), day 4 (haematocrit, HCT) and day 14 (HCT) by study group and G6PD status.

From: Safety of the methylene blue plus chloroquine combination in the treatment of uncomplicated falciparum malaria in young children of Burkina Faso [ISRCTN27290841]

  CQ CQ-MB Group Comparison
Baseline – day 3/4: G6PD deficient children    
Changes in Hb [g/dl] (N = 26) 0.4 ± 1.2 -0.7 ± 1.5 [-0.4; 2.5], pWMW = 0.126
Changes in HCT [%] (N = 30) 1.3 ± 4.1 -1.4 ± 3.9 [-0.9; 6.4], pWMW = 0.259
G6PD sufficient children    
Changes in Hb [g/dl] (N = 176) -0.5 ± 1.3 -0.4 ± 1.6 [-0.6; 0.6], pWMW = 0.906
Changes in HCT [%] (N = 193) -1.2 ± 2.8 -1.1 ± 4.1 [-1.5; 1.3], pWMW = 0.871
Baseline – day 14: G6PD deficient children    
Changes in HCT [%] (N = 30) 1.3 ± 3.3 1.4 ± 3.4 [-3.2; 3.0], pWMW = 0.979
G6PD sufficient children    
Changes in HCT [%] (N = 187) 1.9 ± 3.8 1.2 ± 5.1 [-1.1; 2.5], pWMW = 0.698
  1. Mean ± SD and 95% CI for the mean difference; no difference in change of Hb, HCT between G6PD deficient and sufficient children in the CQ-MB group for Hb (pWMW = 0.538), HCT (day 4, pWMW = 0.897) and HCT (day 14, pWMW = 0.933)