Safety of the methylene blue plus chloroquine combination in the treatment of uncomplicated falciparum malaria in young children of Burkina Faso [ISRCTN27290841]

Table 3 Changes of laboratory values between baseline and study day 3 (haemoglobin, Hb), day 4 (haematocrit, HCT) and day 14 (HCT) by study group and G6PD status.

	CQ	CQ-MB	Group Comparison
Baseline – day 3/4: G6PD deficient children
Changes in Hb [g/dl] (N = 26)	0.4 ± 1.2	-0.7 ± 1.5	[-0.4; 2.5], p_WMW = 0.126
Changes in HCT [%] (N = 30)	1.3 ± 4.1	-1.4 ± 3.9	[-0.9; 6.4], p_WMW = 0.259
G6PD sufficient children
Changes in Hb [g/dl] (N = 176)	-0.5 ± 1.3	-0.4 ± 1.6	[-0.6; 0.6], p_WMW = 0.906
Changes in HCT [%] (N = 193)	-1.2 ± 2.8	-1.1 ± 4.1	[-1.5; 1.3], p_WMW = 0.871
Baseline – day 14: G6PD deficient children
Changes in HCT [%] (N = 30)	1.3 ± 3.3	1.4 ± 3.4	[-3.2; 3.0], p_WMW = 0.979
G6PD sufficient children
Changes in HCT [%] (N = 187)	1.9 ± 3.8	1.2 ± 5.1	[-1.1; 2.5], p_WMW = 0.698

Mean ± SD and 95% CI for the mean difference; no difference in change of Hb, HCT between G6PD deficient and sufficient children in the CQ-MB group for Hb (p_WMW = 0.538), HCT (day 4, p_WMW = 0.897) and HCT (day 14, p_WMW = 0.933)

ISSN: 1475-2875