Cytophilic antibodies to Plasmodium falciparum Glutamate Rich Protein are associated with malaria protection in an area of holoendemic transmission

Table 2 Odds ratio for the risk of febrile malaria episodes

R0-GLURP antibodies	Unadjusted odds ratio (95% CI)¹	P-value	Adjusted odds ratio (95% CI)²	P-value
IgG	0.49 (0.25 – 0.94)	0.031	1.13 (0.50 – 2.53)	0.77
IgG1	0.17 (0.07 – 0.42)	<0.001	0.39 (0.15 – 0.99)	0.047
IgG2	0.47 (0.20 – 1.08)	0.075	1.42 (0.58 – 3.46)	0.445
IgG3	0.25 (0.11 – 0.58)	0.001	0.52 (0.20 – 1.40)	0.197
IgG4	0.42 (0.18 – 0.99)	0.046	0.77 (0.30 – 2.03)	0.602

¹ Logistic regression indicating risk of febrile malaria episode in individuals with detectable plasma levels of anti R0-GLURP antibodies (for IgG, IgG1, IgG2, IgG3 and IgG4, respectively) relative to those without a measurable antibody response. ² Adjusted for the effect of age including age as square root of age.

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