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Table 1 Trends in antimalarial drug resistance in Tanzania, 1950s–1990s

From: Research influence on antimalarial drug policy change in Tanzania: case study of replacing chloroquine with sulfadoxine-pyrimethamine as the first-line drug

Period Resistance pattern to chloroquine up to 1999
Early 1950s A dose of 2.5 mg/kg is still efficacious (grace period)
Mid-1970s Owing to slow increase in resistance, the therapeutic dose was gradually increased to the maximum safe level of 25 mg/kg (alert period)
Late 1980s Resistance to the maximum dose began to reach levels of significant public health importance (alert period)
Mid-1990s WHO recommended drug policy action if resistance (total treatment failure) reaches 25% (change period)
Late 1990s Tanzania established sentinel sites in nine regions to monitor resistance by standard methods
  1. Source: Ministry of Health, 1999.