Skip to main content

Table 2 Seroconversion to measles, diphtheria, tetanus, and pertussis vaccinations in the prophylaxis (CH+) and no prophylaxis (CH-) groups

From: Malaria chemoprophylaxis and the serologic response to measles and diphtheria-tetanus-whole-cell pertussis vaccines

Vaccine Proportion With Seroconversion or Seroresponse (%) P-value
(Adjusted For Village)
Relative Risk (95% CI)
  CH+ CH-   
Measles 127/137(93)* 180/187 (96) 0.16* 0.96 (0.91–1.02)*
  109/116 (94)   0.36 0.98 (0.92–1.03)
Diphtheria 108/147(73)* 116/135 (86) 0.26* 0.86 (0.76–0.96)*
  38/ 46 (83)   0.59 0.96 (0.83–1.12)
Tetanus 104/134(77)* 126/138 (91) 0.08* 0.85 (0.77–0.94)*
  41/43 (95)   0.39 1.04 (0.96–1.14)
Pertussis 63/148(43) * 113/168 (67) <0.01* 0.63 (0.51–0.78)*
  17/44 (39)   <0.01 0.57 (0.39–0.85)
  1. * top rows include all CH+ children (bottom rows include only those CH+ children who met criteria for strict compliance)
  2. † seroconversion is any increase in titer from a negative baseline for measles; seroresponse is a four-fold or greater rise in titer for diphtheria, tetanus, and pertussis
  3. ‡ the discordance between the P-value and confidence interval arises because the latter was calculated from a separate analysis which did not adjust for the random effect of village
\