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Table 2 Seroconversion to measles, diphtheria, tetanus, and pertussis vaccinations in the prophylaxis (CH+) and no prophylaxis (CH-) groups

From: Malaria chemoprophylaxis and the serologic response to measles and diphtheria-tetanus-whole-cell pertussis vaccines

Vaccine

Proportion With Seroconversion or Seroresponse (%)†

P-value

(Adjusted For Village)

Relative Risk (95% CI)

 

CH+

CH-

  

Measles

127/137(93)*

180/187 (96)

0.16*

0.96 (0.91–1.02)*

 

109/116 (94)

 

0.36

0.98 (0.92–1.03)

Diphtheria

108/147(73)*

116/135 (86)

0.26*

0.86 (0.76–0.96)*‡

 

38/ 46 (83)

 

0.59

0.96 (0.83–1.12)

Tetanus

104/134(77)*

126/138 (91)

0.08*

0.85 (0.77–0.94)*‡

 

41/43 (95)

 

0.39

1.04 (0.96–1.14)

Pertussis

63/148(43) *

113/168 (67)

<0.01*

0.63 (0.51–0.78)*

 

17/44 (39)

 

<0.01

0.57 (0.39–0.85)

  1. * top rows include all CH+ children (bottom rows include only those CH+ children who met criteria for strict compliance)
  2. † seroconversion is any increase in titer from a negative baseline for measles; seroresponse is a four-fold or greater rise in titer for diphtheria, tetanus, and pertussis
  3. ‡ the discordance between the P-value and confidence interval arises because the latter was calculated from a separate analysis which did not adjust for the random effect of village
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Malaria Journal

ISSN: 1475-2875

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