Table 2 cDNA microarray analysis of immunomodulator gene expression in P. yoelii 17XL infected mouse brain at peak parasitemia (day eight post-infection).
GENE NAME | FOLD CHANGE EXPRESSION | DESCRIPTION OF GENE |
|---|---|---|
PECAM-1 | 23.0 | Platelet Endothelia Cell Adhesion Molecule-1 |
ICAM-1 | 13.0 | Intercellular Adhesion Molecule-1 |
VCAM-1 | 6.0 | Vascular Cell Adhesion Molecule-1 |
RANTES | 6.0 | Regulated upon Activation Normal T cell Expressed and Secreted |
INF-γ | 6.0 | Interferon-gamma |
TNF | 5.0 | Tumor Necrosis Factor-alpha |
IL-12 | 4.0 | Interleukin-12 |
CCR1 | 4.0 | C-C chemokine receptor 1 |
CCR3 | 4.0 | C-C chemokine receptor 3 |
CCR5 | 4.0 | C-C chemokine receptor 5 |
iNOS | 4.0 | Inducible Nitric Oxide Synthase |
ZO-1 | 2.0 | Zonula Occludin -1 |
IL-4 | 2.0 | Interleukin-4 |
GDF-2 | -2.0 | Growth differentiation factor-2 |
TGF-α | -2.0 | Tumor growth factor-alpha |
GAPDH | 0.0 | Glyceraldehyde-3-Phosphate Dehydrogenase |