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Figure 2 | Malaria Journal

Figure 2

From: Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space?

Figure 2

Current pipeline for the homology-based modelling of malaria protein 3D-structures. This scheme emphasizes on the currently available methods to overcome amino acid bias, low sequence identity, protein inserts etc. Future upgrades include the refinement of each of these methods, for instance implementing asymmetric substitution matrices discussed in the text, that take into account the different amino acid distributions of malarial and non-malarial proteins for pairwise alignments.

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Malaria Journal

ISSN: 1475-2875

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