From: Detection and clinical manifestation of placental malaria in southern Ghana
Diagnostic tool | No. | Low birth weight | Preterm delivery | Anaemia | ||||||
---|---|---|---|---|---|---|---|---|---|---|
% | OR (95%CI) | P | % | OR (95%CI) | P | % | OR (95%CI) | P | ||
Peripheral blood | ||||||||||
Microscopy | ||||||||||
Negative | 680 | 15.8 | 18.4 | 32.9 | ||||||
Positive | 159 | 17.0 | 1.1 (0.7–1.8) | ns | 20.3 | 1.1 (0.7–1.8) | ns | 44.7 | 1.6 (1.1–2.4) | 0.005 |
HRP2 test | ||||||||||
Negative | 553 | 14.3 | 16.5 | 29.5 | ||||||
Positive | 286 | 19.4 | 1.4 (1.0–2.1) | 0.06 | 23.1 | 1.5 (1.1–2.2) | 0.02 | 46.2 | 2.1 (1.5–2.8) | <0.0001 |
PCR | ||||||||||
Negative | 395 | 14.2 | 17.9 | 25.6 | ||||||
Positive | 444 | 17.6 | 1.3 (0.9–1.9) | ns | 19.6 | 1.1 (0.8–1.6) | ns | 43.7 | 2.3 (1.7–3.1) | <0.0001 |
HRP2 test if microscopy negative | ||||||||||
Negative | 542 | 14.2 | 16.5 | 29.3 | ||||||
Positive | 138 | 21.9 | 1.7 (1.0–2.8) | 0.03 | 26.1 | 1.8 (1.1–2.9) | 0.01 | 47.1 | 2.1 (1.4–3.2) | <0.0001 |
PCR if microscopy negative | ||||||||||
Negative | 394 | 14.2 | 17.9 | 25.6 | ||||||
Positive | 286 | 17.9 | 1.3 (0.9–2.0) | ns | 19.1 | 1.1 (0.7–1.6) | ns | 43.0 | 2.2 (1.6–3.1) | <0.0001 |
Placental blood | ||||||||||
Microscopy | ||||||||||
Negative | 546 | 14.3 | 17.7 | 28.8 | ||||||
Positive | 293 | 19.2 | 1.4 (1.0–2.1) | 0.07 | 20.8 | 1.2 (0.8–1.8) | ns | 47.1 | 2.2 (1.6–3.0) | <0.0001 |
Haemozoin | ||||||||||
Negative | 580 | 13.6 | 16.5 | 27.8 | ||||||
Positive | 259 | 21.3 | 1.7 (1.2–2.6) | 0.005 | 23.9 | 1.6 (1.1–2.3) | 0.01 | 51.7 | 2.8 (2.0–3.8) | <0.0001 |
HRP2 test | ||||||||||
Negative | 497 | 12.9 | 16.0 | 27.0 | ||||||
Positive | 342 | 20.5 | 1.8 (1.2–2.6) | 0.003 | 22.8 | 1.6 (1.1–2.2) | 0.01 | 47.1 | 2.4 (1.8–3.3) | <0.0001 |
PCR | ||||||||||
Negative | 341 | 13.5 | 17.5 | 23.8 | ||||||
Positive | 498 | 17.7 | 1.4 (0.9–2.1) | ns | 19.7 | 1.2 (0.8–1.7) | ns | 43.0 | 2.4 (1.8–3.3) | <0.0001 |
Stage of infection | ||||||||||
None | 482 | 13.5 | 16.7 | 27.0 | ||||||
Resolved | 64 | 20.3 | 1.6 (0.8–3.3) | ns | 25.0 | 1.7 (0.9–3.2) | ns | 42.2 | 2.0 (1.1–3.5) | 0.01 |
Late | 195 | 21.6 | 1.8 (1.1–2.8) | 0.009 | 23.6 | 1.5 (1.0–2.4) | 0.04 | 54.9 | 3.3 (2.3–4.7) | <0.0001 |
Early | 98 | 14.3 | 1.1 (0.6–2.1) | ns | 15.5 | 0.9 (0.5–1.7) | ns | 31.6 | 1.3 (0.8–2.1) | ns |