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Table 2 Characteristics of individual treatment arms where genotyping was performed (n = 175).

From: The use of genotyping in antimalarial clinical trials: a systematic review of published studies from 1995–2005

Characteristic

n (%)

Drug regimen

 

   non-artemisinin monotherapy

68 (39%)

   non-artemisinin combination therapy

29 (17%)

   artemisinin monotherapy

6 (3%)

   artemisinin combination therapy

72 (41%)

Total number of patients requiring genotyping *

 

   1–9

42 (24%)

   10–19

30 (17%)

   20–49

54 (31%)

   ≥50

30 (17%)

   no samples to genotype

8 (5%)

   data not available

11 (6%)

Percent of samples successfully genotyped

 

   ≤50%

14 (9%)

   51% – 90%

46 (29%)

   91% – 99%

25 (16%)

   100%

71 (46%)

Percent of successfully genotyped samples classified as new infections

 

   0%

20 (13%)

   1% – 24%

25 (16%)

   25% – 49%

33 (21%)

   50% – 74%

41 (26%)

   75% – 99%

24 (15%)

   100%

12 (8%)

  1. * Total number of patients who experienced recurrent malaria/parasitaemia excluding those patients whose recurrence occurred prior to the earliest day following therapy on which samples were collected for genotyping.
  2. Samples not successfully genotyped include those for which genotyping was not attempted, for which genotyping failed to give a result, or for which genotyping gave indeterminate results.