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Table 2 Clinical and parasitological evolution during follow up by treatment.

From: Safety and efficacy of lumefantrine-artemether (Coartem®) for the treatment of uncomplicated Plasmodium falciparum malaria in Zambian adults

  Day 3 Day 7 Day 14 Day 28
  SP AL P SP AL P SP AL P SP AL P
N 430 451   405 436   384 406   290 320  
Fever (%) 3.5 0.9 0.007 1.0 1.1 0.55 1.3 1.0 0.75 2.7 1.2 0.19
Parasitaemia 15.0 0.7 <0.001 2.0 0.0 NA 2, 0;5 0.009 5.5 1.2 0.003
Hemoglobin (mean)*(g/L) - -   - -   124 129 0.003 130 134 0.02
Gametocyte carriage (N (%)) 33 (7.6) 3 (0.7) <0.001 88 (21.6) 2 (0.5) <0.001 76 (19.8) 0 (0) NA 10 (4.5) 1 (0,3) 0.004
Gametocyte densities (range) 48.6 (1–4320) 6.2 (1–240) 0.62 63.6 (1–4480) 8.9 (1–80) 0.51 52.8 (1–6960) 0(0) NA 154.9 (3–840) 160 NA
N 430 448   400 428   382 401   303 329  
Weakness (%) 46.3 20.5 <0.001 15.0 6.1 <0.001 7.1 3.7 0.04 5.9 3.0 0.08
Headache (%) 45.6 22.5 <0.001 18.0 12.2 0.02 10.7 8.5 0.28 11.5 10.3 0.62
Muscle joint pain (%) 20.3 8.2 <0.001 5.2 2.6 0.004 3.8 2.8 0.47 2.3 2.8 0.73
Dizziness (%) 20.0 10.8 <0.001 5.2 3.0 0.11 2.1 1.0 0.21 2.7 1.2 0.18
Nausea (%) 15.8 2.9 <0.001 1.3 0.0 NA 0.8 0.5 NA 0.7 0.6 NA
Vomiting (%) 5.8 0.7 <0.001 0.5 0.2 NA 0.5 0.5 NA 0.0 0.3 NA
Diarrhoea (%) 3.8 7.7 0.013 0,9 2.5 0.08 1.3 2.7 0.16 0.7 1.2 0.78
Abdominal pain (%) 16.7 9.2 <0.001 7.0 4.0 0.06 3.4 3.5 0.94 5.0 3.7 0.41
Hear palpitations (%) 9.8 5.1 0.008 5.5 4.2 0.38 5.8 8.0 0.61 4.6 7.3 0.88
Back ache (%) 10.9 8.9 0.32 7.0 7.7 0.53 5.8 8.0 0.22 4.6 7.3 0.15
  1. In bold P value < 0,05; Other symptoms had low frequency or were not significantly different at day 3. Fisher exact (2-tailed) used where indicated. No significant differences at day 45 (data not shown). NS = not significant/NA = not applicable. * Haemoglobine day 14 and day 45 (P value: Barlett's test)
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