Table 2 Proportions of point mutations on dhfr and dhps related to parasite resistance to antifolates
From: Drug resistance to sulphadoxine-pyrimethamine in Plasmodium falciparum malaria in Mlimba, Tanzania
Resistance to | Gene locus | Mutations (%) | Wild type (%) | Mixed (%) | Total |
|---|---|---|---|---|---|
Pyrimethamine | DHFR 51 | 74 (62.7%) | 35 (29.7%) | 9 (7.6%) | 118 |
| Â | DHFR 59 | 59 (48.8%) | 36 (29.8%) | 26 (21.5%) | 121 |
| Â | DHFR 108 | 81 (66.9%) | 17 (14.1%) | 23 (19.0%) | 121 |
| Â | DHFR 164 | 0 (0.0%) | 104 (100.0%) | 0 (0.0%) | 104 |
Sulphadoxine | DHPS 437 | 56 (43.7%) | 71 (55.5%) | 1 (0.8%) | 128 |
| Â | DHPS 540 | 47 (39.2%) | 65 (54.5%) | 8 (6.3%) | 120 |
| Â | DHPS 581 | 1 (0.8%) | 126 (98.4%) | 1 (0.8%) | 128 |
| Â | Â | 318 | 454 | 68 | 840 |