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Table 3 A. Sensitivity and specificity of all three molecular techniques and microscopy using molecular consensus as the gold standard; and B. microscopy as the gold standard

From: Comparison of three molecular methods for the detection and speciation of Plasmodium vivax and Plasmodium falciparum

A
Molecular consensus as gold standard P. falciparum P. vivax Mixed Infection
  Sensitivity (%) Specificity (%) Sensitivity (%) Specificity (%) Sensitivity (%) Specificity (%)
Multiplex 100 (40/40+0) 100 (96/96+0) 92.7 (51/51+4) 100 (81/81+0) 0 (0/0+3) 100 (133/133+0)
Nested 100 (40/40+0) 99 (95/95+1) 100 (54/54+0) 100 (82/82+0) 100 (3/3+0) 99.2 (132/132+1)
Real-time 100 (40/40+0) 100 (96/96+0) 100 (51/51+0) 100 (85/85+0) 100 (3/3+0) 100 (133/133+0)
Microscopy 92.5 (37/37+3) 100 (96/96+0) 90.7 (49/49+5) 91.5 (75/75+7) 66.7 (2/2+1) 98.5 (131/131+2)
B
Microscopy as gold standard P. falciparum P. vivax Mixed Infection
  Sensitivity (%) Specificity (%) Sensitivity (%) Specificity (%) Sensitivity (%) Specificity (%)
Multiplex 100 (37/37+0) 97 (96/96+3) 83.9 (47/47+9) 95 (76/76+4) 0 (0/0+4) 100.00 (132/132+0)
Nested 100 (37/37+0) 96 (95/95+4) 87.5 (49/49+7) 93.8 (75/75+5) 50 (2/2+2) 98.5 (130/130+2)
Real-time 100 (37/37+0) 97 (96/96+3) 87.5 (49/49+7) 93.8 (75/75+5) 50 (2/2+2) 99.2 (131/131+1)
  1. Sensitivity equals the number of true positives divided by the number of true positives and false negatives combined. Specificity equals the number of true negatives divided by the number of true negatives and false positives combined.