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Table 1 Main characteristics of the area and intervention in Ifakara and Manhiça

From: Varying efficacy of intermittent preventive treatment for malaria in infants in two similar trials: public health implications

  Ifakara Manhiça
Years of intervention 1999–2001 2002–2004
Number of children randomized 701 1503
Incidence of malaria in placebo group a 0.36 0.43
EIR* 29 38
Transmission Perennial Perennial with marked seasonality
IPTi regimen** 2, 3, 9 3, 4, 9
Iron supplementation** 2–6 -
1st line Malaria Treatment during study SP SP + AQ
ITN use 68% 0
HIV seroprevalence (at ANC) 6.7% 19%
Hb AS prevalence *** 12% 0
SP parasitological sensitivity# 69% (62/90) 78.6% (55/70)
SP ACR# 94% (84/89) 83% (67/81)
  1. *EIR = Entomological inoculation rate
  2. **months of age
  3. *** hemoglobin AS genotype
  4. # at day 14. ACR = adequate clinical response
  5. a episode/child/year