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Table 1 Means of raw and loge-transformed IC50s, geometric means and Geometric Least Squares Means.

From: Geometric least squares means ratios for the analysis of Plasmodium falciparum in vitro susceptibility to antimalarial drugs

1997 2000 2001 2002 2003 2004 Normality
Variable N Mean STD N Mean STD N Mean STD N Mean STD N Mean STD N Mean STD p-value
Means (raw values)
CQ 31 236 203.4 33 173.2 223 31 251.4 236.7 46 131.3 104 34 143.8 91.03 67 171.5 157.2 0.01
QN 46 234.6 150.2 28 305.8 210.4 31 444 286.2 40 252.6 273.6 34 280.8 162.8 58 207.5 149.8 0.01
MdAQ 45 12.8 12.4 33 85.1 167.8 31 57.7 63.2 43 42.9 32.3 34 31.1 21.3 64 21.7 17.6 0.01
ART 10 3.6 0.8 31 9.8 12.0 31 6.1 6.6 40 5.7 4.5 34 7.4 5.9 36 7.5 5.0 0.01
Means (natural log values)
CQ 31 4.9 1.4 33 4.4 1.2 31 5 1.2 46 4.5 0.9 34 4.7 0.8 67 4.7 1 0.01
QN 46 5.2 0.8 28 5.5 0.8 31 5.9 0.7 40 5.1 0.9 34 5.5 0.5 58 5.1 0.8 0.04
MdAQ 45 2.1 0.9 33 3.8 1.0 31 3.6 0.9 43 3.5 0.7 34 3.2 0.6 64 2.8 0.9 0.04
ART 10 1.2 0.3 31 1.8 1.0 31 1.3 1 40 1.3 1.0 34 1.8 0.6 36 1.8 0.7 0.15
Geometric means
CQ 31 130.3 3.9 33 82.3 3.5 31 148.4 3.2 46 93.7 2.5 34 112.2 2.2 67 115.6 2.7 -
QN 46 181.3 2.3 28 237.5 2.2 31 350.7 2.1 40 169.0 2.6 34 244.7 1.7 58 162.4 2.1 -
MdAQ 45 8.5 2.5 33 43.8 2.7 31 38.5 2.4 43 33.1 2.1 34 25.3 1.9 64 15.8 2.4 -
ART 10 3.5 1.3 31 5.8 2.7 31 3.9 2.7 40 3.9 2.8 34 6.1 1.9 36 6.0 2.0 -
Geometric Least Squares Means
CQ 31 130.8 1.2 33 82.6 1.2 31 148.4 1.2 46 93.3 1.2 34 112.7 1.2 67 115 1.1 -
QN 46 181.3 1.1 28 238.2 1.2 31 350.1 1.1 40 168.4 1.1 34 245 1.1 58 162.2 1.1 -
MdAQ 45 8.5 1.1 33 44 1.2 31 38.5 1.2 43 33.1 1.1 34 25.3 1.2 64 15.9 1.1 -
ART 10 3.5 1.3 31 5.8 1.2 31 3.9 1.2 40 3.9 1.1 34 6.1 1.2 36 6.0 1.1 -
  1. P-values are from the Kolmogorov-Smirnov test for normality. CQ = chloroquine; QN = quinine; MdAQ = monodesethylamodiaquine; ART = artemisinin
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Malaria Journal

ISSN: 1475-2875

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