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Table 1 Means of raw and loge-transformed IC50s, geometric means and Geometric Least Squares Means.

From: Geometric least squares means ratios for the analysis of Plasmodium falciparum in vitro susceptibility to antimalarial drugs

1997

2000

2001

2002

2003

2004

Normality

Variable

N

Mean

STD

N

Mean

STD

N

Mean

STD

N

Mean

STD

N

Mean

STD

N

Mean

STD

p-value

Means (raw values)

CQ

31

236

203.4

33

173.2

223

31

251.4

236.7

46

131.3

104

34

143.8

91.03

67

171.5

157.2

0.01

QN

46

234.6

150.2

28

305.8

210.4

31

444

286.2

40

252.6

273.6

34

280.8

162.8

58

207.5

149.8

0.01

MdAQ

45

12.8

12.4

33

85.1

167.8

31

57.7

63.2

43

42.9

32.3

34

31.1

21.3

64

21.7

17.6

0.01

ART

10

3.6

0.8

31

9.8

12.0

31

6.1

6.6

40

5.7

4.5

34

7.4

5.9

36

7.5

5.0

0.01

Means (natural log values)

CQ

31

4.9

1.4

33

4.4

1.2

31

5

1.2

46

4.5

0.9

34

4.7

0.8

67

4.7

1

0.01

QN

46

5.2

0.8

28

5.5

0.8

31

5.9

0.7

40

5.1

0.9

34

5.5

0.5

58

5.1

0.8

0.04

MdAQ

45

2.1

0.9

33

3.8

1.0

31

3.6

0.9

43

3.5

0.7

34

3.2

0.6

64

2.8

0.9

0.04

ART

10

1.2

0.3

31

1.8

1.0

31

1.3

1

40

1.3

1.0

34

1.8

0.6

36

1.8

0.7

0.15

Geometric means

CQ

31

130.3

3.9

33

82.3

3.5

31

148.4

3.2

46

93.7

2.5

34

112.2

2.2

67

115.6

2.7

-

QN

46

181.3

2.3

28

237.5

2.2

31

350.7

2.1

40

169.0

2.6

34

244.7

1.7

58

162.4

2.1

-

MdAQ

45

8.5

2.5

33

43.8

2.7

31

38.5

2.4

43

33.1

2.1

34

25.3

1.9

64

15.8

2.4

-

ART

10

3.5

1.3

31

5.8

2.7

31

3.9

2.7

40

3.9

2.8

34

6.1

1.9

36

6.0

2.0

-

Geometric Least Squares Means

CQ

31

130.8

1.2

33

82.6

1.2

31

148.4

1.2

46

93.3

1.2

34

112.7

1.2

67

115

1.1

-

QN

46

181.3

1.1

28

238.2

1.2

31

350.1

1.1

40

168.4

1.1

34

245

1.1

58

162.2

1.1

-

MdAQ

45

8.5

1.1

33

44

1.2

31

38.5

1.2

43

33.1

1.1

34

25.3

1.2

64

15.9

1.1

-

ART

10

3.5

1.3

31

5.8

1.2

31

3.9

1.2

40

3.9

1.1

34

6.1

1.2

36

6.0

1.1

-

  1. P-values are from the Kolmogorov-Smirnov test for normality. CQ = chloroquine; QN = quinine; MdAQ = monodesethylamodiaquine; ART = artemisinin