Skip to main content

Table 2 Pairwise Least Squares Means comparisons following ANOVA of chloroquine (CQ), monodesethylamodiaquine (MdAQ), Quinine (QN) and Artemisinin (ART) loge-transformed IC50 (nM) between years.

From: Geometric least squares means ratios for the analysis of Plasmodium falciparum in vitro susceptibility to antimalarial drugs

  MdAQ CQ QN ART
year Comparison Difference Between Means Simultaneous 95% Confidence Limits   Sig. Difference Between Means Simultaneous 95% Confidence Limits   Sig. Difference Between Means Simultaneous 95% Confidence Limits   Sig. Difference Between Means Simultaneous 95% Confidence Limits   Sig.
1997 – 2000 -1.6 -2.3 -1.0 *** 0.5 -0.4 1.4   -0.3 -0.9 0.4   -0.5 -1.6 0.5  
1997 – 2001 -1.5 -2.2 -0.8 *** -0.1 -1.0 0.8   -0.7 -1.3 0.0 *** -0.1 -1.2 0.9  
1997 – 2002 -1.4 -2.0 -0.7 *** 0.3 -0.5 1.2   0.1 -0.5 0.6   -0.1 -1.1 0.9  
1997 – 2003 -1.1 -1.7 -0.4 *** 0.1 -0.7 1.0   -0.3 -0.9 0.3   -0.6 -1.6 0.5  
1997 – 2004 -0.6 -1.2 -0.1 *** 0.1 -0.6 0.9   0.1 -0.4 0.6   -0.5 -1.6 0.5  
2000 – 1997 1.6 1.0 2.3 *** -0.5 -1.4 0.4   0.3 -0.4 0.9   0.5 -0.5 1.6  
2000 – 2001 0.1 -0.6 0.8   -0.6 -1.5 0.3   -0.4 -1.1 0.3   0.4 -0.3 1.1  
2000 – 2002 0.3 -0.4 0.9   -0.1 -0.9 0.7   0.3 -0.3 1.0   0.4 -0.3 1.1  
2000 – 2003 0.6 -0.1 1.2   -0.3 -1.2 0.6   0.0 -0.7 0.6   -0.1 -0.8 0.7  
2000 – 2004 1.0 0.4 1.6 *** -0.3 -1.1 0.4   0.4 -0.2 1.0   0.0 -0.7 0.7  
2001 – 1997 1.5 0.8 2.2 *** 0.1 -0.8 1.0   0.7 0.0 1.3 *** 0.1 -0.9 1.2  
2001 – 2000 -0.1 -0.8 0.6   0.6 -0.3 1.5   0.4 -0.3 1.1   -0.4 -1.1 0.3  
2001 – 2002 0.2 -0.5 0.8   0.5 -0.4 1.3   0.7 0.1 1.4 *** 0.0 -0.7 0.7  
2001 – 2003 0.4 -0.3 1.1   0.3 -0.6 1.2   0.4 -0.3 1.0   -0.5 -1.2 0.3  
2001 – 2004 0.9 0.3 1.5 *** 0.3 -0.5 1.0   0.8 0.2 1.4 *** -0.4 -1.2 0.3  
2002 – 1997 1.4 0.7 2.0 *** -0.3 -1.2 0.5   -0.1 -0.6 0.5   0.1 -0.9 1.1  
2002 – 2000 -0.3 -0.9 0.4   0.1 -0.7 0.9   -0.3 -1.0 0.3   -0.4 -1.1 0.3  
2002 – 2001 -0.2 -0.8 0.5   -0.5 -1.3 0.4   -0.7 -1.4 -0.1 *** 0.0 -0.7 0.7  
2002 – 2003 0.3 -0.4 0.9   -0.2 -1.0 0.6   -0.4 -1.0 0.2   -0.5 -1.1 0.2  
2002 – 2004 0.7 0.2 1.3 *** -0.2 -0.9 0.5   0.0 -0.5 0.6   -0.4 -1.1 0.2  
2003 – 1997 1.1 0.4 1.7 *** -0.1 -1.0 0.7   0.3 -0.3 0.9   0.6 -0.5 1.6  
2003 – 2000 -0.6 -1.2 0.1   0.3 -0.6 1.2   0.0 -0.6 0.7   0.1 -0.7 0.8  
2003 – 2001 -0.4 -1.1 0.3   -0.3 -1.2 0.6   -0.4 -1.0 0.3   0.5 -0.3 1.2  
2003 – 2002 -0.3 -0.9 0.4   0.2 -0.6 1.0   0.4 -0.2 1.0   0.5 -0.2 1.1  
2003 – 2004 0.5 -0.1 1.1   0.0 -0.8 0.7   0.4 -0.2 1.0   0.0 -0.7 0.7  
2004 – 1997 0.6 0.1 1.2 *** -0.1 -0.9 0.6   -0.1 -0.6 0.4   0.5 -0.5 1.6  
2004 – 2000 -1.0 -1.6 -0.4 *** 0.3 -0.4 1.1   -0.4 -1.0 0.2   0.0 -0.7 0.7  
2004 – 2001 -0.9 -1.5 -0.3 *** -0.3 -1.0 0.5   -0.8 -1.4 -0.2 *** 0.4 -0.3 1.2  
2004 – 2002 -0.7 -1.3 -0.2 *** 0.2 -0.5 0.9   0.0 -0.6 0.5   0.4 -0.2 1.1  
2004 – 2003 -0.5 -1.1 0.1   0.0 -0.7 0.8   -0.4 -1.0 0.2   0.0 -0.7 0.7