Table 2 Pairwise Least Squares Means comparisons following ANOVA of chloroquine (CQ), monodesethylamodiaquine (MdAQ), Quinine (QN) and Artemisinin (ART) loge-transformed IC50 (nM) between years.
MdAQ | CQ | QN | ART | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
year Comparison | Difference Between Means | Simultaneous 95% Confidence Limits | Sig. | Difference Between Means | Simultaneous 95% Confidence Limits | Sig. | Difference Between Means | Simultaneous 95% Confidence Limits | Sig. | Difference Between Means | Simultaneous 95% Confidence Limits | Sig. | ||||
1997 – 2000 | -1.6 | -2.3 | -1.0 | *** | 0.5 | -0.4 | 1.4 | -0.3 | -0.9 | 0.4 | -0.5 | -1.6 | 0.5 | |||
1997 – 2001 | -1.5 | -2.2 | -0.8 | *** | -0.1 | -1.0 | 0.8 | -0.7 | -1.3 | 0.0 | *** | -0.1 | -1.2 | 0.9 | ||
1997 – 2002 | -1.4 | -2.0 | -0.7 | *** | 0.3 | -0.5 | 1.2 | 0.1 | -0.5 | 0.6 | -0.1 | -1.1 | 0.9 | |||
1997 – 2003 | -1.1 | -1.7 | -0.4 | *** | 0.1 | -0.7 | 1.0 | -0.3 | -0.9 | 0.3 | -0.6 | -1.6 | 0.5 | |||
1997 – 2004 | -0.6 | -1.2 | -0.1 | *** | 0.1 | -0.6 | 0.9 | 0.1 | -0.4 | 0.6 | -0.5 | -1.6 | 0.5 | |||
2000 – 1997 | 1.6 | 1.0 | 2.3 | *** | -0.5 | -1.4 | 0.4 | 0.3 | -0.4 | 0.9 | 0.5 | -0.5 | 1.6 | |||
2000 – 2001 | 0.1 | -0.6 | 0.8 | -0.6 | -1.5 | 0.3 | -0.4 | -1.1 | 0.3 | 0.4 | -0.3 | 1.1 | ||||
2000 – 2002 | 0.3 | -0.4 | 0.9 | -0.1 | -0.9 | 0.7 | 0.3 | -0.3 | 1.0 | 0.4 | -0.3 | 1.1 | ||||
2000 – 2003 | 0.6 | -0.1 | 1.2 | -0.3 | -1.2 | 0.6 | 0.0 | -0.7 | 0.6 | -0.1 | -0.8 | 0.7 | ||||
2000 – 2004 | 1.0 | 0.4 | 1.6 | *** | -0.3 | -1.1 | 0.4 | 0.4 | -0.2 | 1.0 | 0.0 | -0.7 | 0.7 | |||
2001 – 1997 | 1.5 | 0.8 | 2.2 | *** | 0.1 | -0.8 | 1.0 | 0.7 | 0.0 | 1.3 | *** | 0.1 | -0.9 | 1.2 | ||
2001 – 2000 | -0.1 | -0.8 | 0.6 | 0.6 | -0.3 | 1.5 | 0.4 | -0.3 | 1.1 | -0.4 | -1.1 | 0.3 | ||||
2001 – 2002 | 0.2 | -0.5 | 0.8 | 0.5 | -0.4 | 1.3 | 0.7 | 0.1 | 1.4 | *** | 0.0 | -0.7 | 0.7 | |||
2001 – 2003 | 0.4 | -0.3 | 1.1 | 0.3 | -0.6 | 1.2 | 0.4 | -0.3 | 1.0 | -0.5 | -1.2 | 0.3 | ||||
2001 – 2004 | 0.9 | 0.3 | 1.5 | *** | 0.3 | -0.5 | 1.0 | 0.8 | 0.2 | 1.4 | *** | -0.4 | -1.2 | 0.3 | ||
2002 – 1997 | 1.4 | 0.7 | 2.0 | *** | -0.3 | -1.2 | 0.5 | -0.1 | -0.6 | 0.5 | 0.1 | -0.9 | 1.1 | |||
2002 – 2000 | -0.3 | -0.9 | 0.4 | 0.1 | -0.7 | 0.9 | -0.3 | -1.0 | 0.3 | -0.4 | -1.1 | 0.3 | ||||
2002 – 2001 | -0.2 | -0.8 | 0.5 | -0.5 | -1.3 | 0.4 | -0.7 | -1.4 | -0.1 | *** | 0.0 | -0.7 | 0.7 | |||
2002 – 2003 | 0.3 | -0.4 | 0.9 | -0.2 | -1.0 | 0.6 | -0.4 | -1.0 | 0.2 | -0.5 | -1.1 | 0.2 | ||||
2002 – 2004 | 0.7 | 0.2 | 1.3 | *** | -0.2 | -0.9 | 0.5 | 0.0 | -0.5 | 0.6 | -0.4 | -1.1 | 0.2 | |||
2003 – 1997 | 1.1 | 0.4 | 1.7 | *** | -0.1 | -1.0 | 0.7 | 0.3 | -0.3 | 0.9 | 0.6 | -0.5 | 1.6 | |||
2003 – 2000 | -0.6 | -1.2 | 0.1 | 0.3 | -0.6 | 1.2 | 0.0 | -0.6 | 0.7 | 0.1 | -0.7 | 0.8 | ||||
2003 – 2001 | -0.4 | -1.1 | 0.3 | -0.3 | -1.2 | 0.6 | -0.4 | -1.0 | 0.3 | 0.5 | -0.3 | 1.2 | ||||
2003 – 2002 | -0.3 | -0.9 | 0.4 | 0.2 | -0.6 | 1.0 | 0.4 | -0.2 | 1.0 | 0.5 | -0.2 | 1.1 | ||||
2003 – 2004 | 0.5 | -0.1 | 1.1 | 0.0 | -0.8 | 0.7 | 0.4 | -0.2 | 1.0 | 0.0 | -0.7 | 0.7 | ||||
2004 – 1997 | 0.6 | 0.1 | 1.2 | *** | -0.1 | -0.9 | 0.6 | -0.1 | -0.6 | 0.4 | 0.5 | -0.5 | 1.6 | |||
2004 – 2000 | -1.0 | -1.6 | -0.4 | *** | 0.3 | -0.4 | 1.1 | -0.4 | -1.0 | 0.2 | 0.0 | -0.7 | 0.7 | |||
2004 – 2001 | -0.9 | -1.5 | -0.3 | *** | -0.3 | -1.0 | 0.5 | -0.8 | -1.4 | -0.2 | *** | 0.4 | -0.3 | 1.2 | ||
2004 – 2002 | -0.7 | -1.3 | -0.2 | *** | 0.2 | -0.5 | 0.9 | 0.0 | -0.6 | 0.5 | 0.4 | -0.2 | 1.1 | |||
2004 – 2003 | -0.5 | -1.1 | 0.1 | 0.0 | -0.7 | 0.8 | -0.4 | -1.0 | 0.2 | 0.0 | -0.7 | 0.7 | ||||