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Table 1 Physiological and clinical variables during first 7 days of RICU stay demonstrating the effect of the infusion of Drotrecogin alfa (activated) on days 1–4.

From: Severe sepsis due to severe falciparum malaria and leptospirosis co-infection treated with activated protein C

Variables Day 0 Day 1 Day 2 Day 3 Day 4 Day 5 Day 6 Day 7
Heart rate (/minute) 128 111 120 116 106 100 92 86
Respiratory rate (/minute) 46 32 36 30 28 28 24 22
Temperature (C) 39 38.5 38.4 38 37 37 37 37.2
pH 7.2 7.25 7.26 7.3 7.34 7.42 7.44 -
PaO2/FiO2 168 180 130 230 260 290 340 -
HCO3 (mEq/L) 13 15 14 18 20 22 22 -
Ventilatory mode Spontaneous ACMV ACMV ACMV PSV T-piece Spontaneous Spontaneous
PEEP (cm H20) - 8 10 6 5 - - -
Serum creatinine (mg/dL) 5.2 6.0 5.2 7.1 4.6 4.4 4.0 3.6
Urine output (mL/24 hours) 460 100 110 200 240 200 270 560
Serum bilirubin (mg/dL) 18.2 18.9 18.2 15.4 9.1 8.4 6.0 4.2
Total leucocyte count (/μL) 19000 19500 18200 14400 11400 8100 8000 8100
Platelet count (/μL) 92000 105,000 155,000 183,000 212,000 241,000 260,000 270,000