Table 1 Demographics, admission clinical and laboratory data of patients with acute uncomplicated falciparum malaria who were treated with fosmidomycin monotherapy and combination therapy with clindamycin. Data are presented as median (95% C.I.) or number of patients and percentage (n, %) values.
Characteristics | Fosmidomycin monotherapy (N = 15) | Fosmidomycin + Clindamycin (N = 18) |
|---|---|---|
Age (yr) | 36 (19–45) | 29 (18–48) |
Body weight (kg) | 55 (42–67) | 56 (40–75) |
Male/Female | 11/4 | 13/5 |
Ethnic: | Â | Â |
   Thai | 5 | 10 |
   Karen | 2 | 3 |
   Burmese | 8 | 5 |
Body temperature (°C) | 38.3 (36.0–40.0) | 38.0 (37.3–39.9) |
Baseline asexual form parasitaemia (/μl)a | 11,747 (1,141–173,880) | 30,600 (944–67,640) |
Haemoglobin (mg/dl) | 12.4 (8.0–15.5) | 12.6 (8.1–15.0) |
Haematocrit (%) | 38.6 (26.5–44.8) | 39.8 (25.5–45.7) |
WBC (x109/l) | 5.8 (3.5–8.7) | 6.0 (3.0–8.9) |
Platelet count (x109/l) | 78 (22–230) | 80 (21–225) |
Total bilirubin (mg/dl) | 1.5 (0.3–2.5) | 1.3 (0.1–2.6) |
ALT (IU/l) | 25 (10–98) | 24 (8–103) |
Creatinine (mg/dl) | 1.2 (0.9–1.8) | 1.1 (0.7–1.9) |
BUN (mg/dl) | 13 (9–40) | 14 (7–43) |
Total protein (mg/dl) | 6.2 (5.3–8.1) | 6.0 (5.0–8.0) |
Albumin (g/dl) | 3.8 (3.0–4.6) | 3.6 (2.9–4.5) |
Glucose (mg/dl) | 118 (80–198) | 110 (79–205) |