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Table 1 Demographics, admission clinical and laboratory data of patients with acute uncomplicated falciparum malaria who were treated with fosmidomycin monotherapy and combination therapy with clindamycin. Data are presented as median (95% C.I.) or number of patients and percentage (n, %) values.

From: Pharmacokinetics and pharmacodynamics of fosmidomycin monotherapy and combination therapy with clindamycin in the treatment of multidrug resistant falciparum malaria

Characteristics Fosmidomycin monotherapy (N = 15) Fosmidomycin + Clindamycin (N = 18)
Age (yr) 36 (19–45) 29 (18–48)
Body weight (kg) 55 (42–67) 56 (40–75)
Male/Female 11/4 13/5
Ethnic:   
   Thai 5 10
   Karen 2 3
   Burmese 8 5
Body temperature (°C) 38.3 (36.0–40.0) 38.0 (37.3–39.9)
Baseline asexual form parasitaemia (/μl)a 11,747 (1,141–173,880) 30,600 (944–67,640)
Haemoglobin (mg/dl) 12.4 (8.0–15.5) 12.6 (8.1–15.0)
Haematocrit (%) 38.6 (26.5–44.8) 39.8 (25.5–45.7)
WBC (x109/l) 5.8 (3.5–8.7) 6.0 (3.0–8.9)
Platelet count (x109/l) 78 (22–230) 80 (21–225)
Total bilirubin (mg/dl) 1.5 (0.3–2.5) 1.3 (0.1–2.6)
ALT (IU/l) 25 (10–98) 24 (8–103)
Creatinine (mg/dl) 1.2 (0.9–1.8) 1.1 (0.7–1.9)
BUN (mg/dl) 13 (9–40) 14 (7–43)
Total protein (mg/dl) 6.2 (5.3–8.1) 6.0 (5.0–8.0)
Albumin (g/dl) 3.8 (3.0–4.6) 3.6 (2.9–4.5)
Glucose (mg/dl) 118 (80–198) 110 (79–205)
  1. ageometric mean (range)