Table 3 Pharmacokinetics of fosmidomycin and clindamycin analysed by one-compartment model with first order absorption and elimination with absorption lag-time. Data are presented as median (%C.V) values.
Pharmacokinetic parameters | Fosmidomycin monotherapy (N = 15) | Fosmidomycin + Clindamycin (N = 18) | |
|---|---|---|---|
| Â | Â | Fosmidomycin | Clindamycin |
Cmax (μg/ml) | 3.95 (12.8) | 4.06 (6.8) | 5.98 (5.1) |
tmax (hr) | 2.24 (28.1) | 2.46 (11.6) | 1.14 (2.4) |
K01 (/hr) | 1.27 (104.3) | 1.17 (2.5) | 3.99 (111.3) |
K10 (/hr) | 0.20 (24.7) | 0.18 (12.5) | 0.22(0.1) |
tlag (hr) | 0.5 (83.3) | 0.6 (15.4) | 0.38(17.6) |
AUC0, (μg.hr/ml) | 27.67 (7.6) | 35.59 (4.1) | 31.9(75.9) |
t1/2a (hr) | 0.5 (104.0) | 0.6 (39.9) | 0.17(4.8) |
t1/2e (hr) | 3.4 (24.7) | 3.8 (13.0) | 3.11(0.7) |
Vz/F (l) | 214.00 (27.4) | 138.00 (14.9) | 84 (21.0) |
CL/F (l/hr) | 433.66 (7.7) | 252.85(4.1) | 18.79(44.0) |