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Table 3 Pharmacokinetics of fosmidomycin and clindamycin analysed by one-compartment model with first order absorption and elimination with absorption lag-time. Data are presented as median (%C.V) values.

From: Pharmacokinetics and pharmacodynamics of fosmidomycin monotherapy and combination therapy with clindamycin in the treatment of multidrug resistant falciparum malaria

Pharmacokinetic parameters Fosmidomycin monotherapy (N = 15) Fosmidomycin + Clindamycin (N = 18)
   Fosmidomycin Clindamycin
Cmax (μg/ml) 3.95 (12.8) 4.06 (6.8) 5.98 (5.1)
tmax (hr) 2.24 (28.1) 2.46 (11.6) 1.14 (2.4)
K01 (/hr) 1.27 (104.3) 1.17 (2.5) 3.99 (111.3)
K10 (/hr) 0.20 (24.7) 0.18 (12.5) 0.22(0.1)
tlag (hr) 0.5 (83.3) 0.6 (15.4) 0.38(17.6)
AUC0, (μg.hr/ml) 27.67 (7.6) 35.59 (4.1) 31.9(75.9)
t1/2a (hr) 0.5 (104.0) 0.6 (39.9) 0.17(4.8)
t1/2e (hr) 3.4 (24.7) 3.8 (13.0) 3.11(0.7)
Vz/F (l) 214.00 (27.4) 138.00 (14.9) 84 (21.0)
CL/F (l/hr) 433.66 (7.7) 252.85(4.1) 18.79(44.0)
  1. k01 = absorption rate constant; k10 = elimination rate constant; tlag= absorption lag time; t1/2a = absorption half-life; t1/2e= elimination half-life