Figure 1

Age-specific seroconversion to P. falciparum -infected erythrocyte variant surface antigens according to α⁺-thalassaemia genotype. Antibody levels are expressed as the percentage relative response to a hyper-immune plasma control (HIP). Data represent the predicted antibody levels from a mixed linear model including age, P. falciparum parasitaemia (with parasitaemia set to 0) and α⁺-thalassaemia genotype. There was statistical significance between children of normal genotype and children heterozygous for α⁺-thalassaemia only (P = 0.02).