Figure 3From: Polymorphisms of TNF-enhancer and gene for FcγRIIa correlate with the severity of falciparum malaria in the ethnically diverse Indian populationLinkage between TNF regulatory region SNPs and correlation of TNF haplotypes with plasma TNF levels. A, r2 LD plot of four TNF SNPs (-1031, -863, -308, -238). Value in each cell is the percent D' between SNP pairs. B, Correlation of TNF promoter haplotype (-1031C, -863A, -857C, -308G, -238G) with elevated TNF levels compared to the major haplotype TCCGG. Mean plasma TNF levels were compared using Mann-Whitney test (z = -3.73, P = 0.0002). C, Plasma TNF level in patients and controls. Pairwise comparison of means by non-parametric Mann-Whitney test: severe versus control, z = 4.41, P < 0.0001; non-severe versus control, z = 0.67, P = 0.25; severe versus non-severe, z = 3.13, P = 0.0009.Back to article page