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Table 2 Day 28 failure rates estimated by four methods – AS+AQ treatment

From: Different methodological approaches to the assessment of in vivo efficacy of three artemisinin-based combination antimalarial treatments for the treatment of uncomplicated falciparum malaria in African children

   Day 28 failure rates
% [CI95%]
Year Country &
Site
Method 1a
(per protocol)
Method 1b Method 2a
(WHO 2001)
Method 2b
2003 Angola, Kuito 1.3 1.2 1.2 1.2
   [0–6.8] [0–6.4] [0.2–8.3] [0.2–8.1]
2003 DRC, Boende 18.3 14.1 15.3 56.3
   [9.5–30.4] [7.2–23.8] [8.7–25.9] [45.8–67.4]
2003 S Sudan, Nuba 7.3 5.6 6.2 8.4
   [2.0–17.6] [1.5–12.6] [2.4–15.7] [3.9–18.0]
2003 Uganda, Amudat 22.6 8.8 10.4 21.4
   [9.6–41.1] [3.6–17.2] [4.9–21.1] [14.0–31.8]
2003 Uganda, Jinja 7.9 6.5 7.0 12.2
   [3.2–15.7] [2.7–13.0] [3.4–14.1] [7.2–20.1]
2003 Uganda, Kampala 4.9 4.1 4.3 4.3
   [1.0–13.7] [0.9–11.5] [1.4–12.8] [1.4–12.9]
2004 Angola, Caala 0 0 0 1.5
   [0–6.0]* [0–5.7]* [0–5.8]* [0.2–10.4]
2004 Congo, Kindamba 6.0 4.8 4.8 6.4
   [1.6–14.6] [1.3–11.9] [1.8–12.2] [2.9–13.7]
2004 DRC, Kabalo 0 0 0 4.4
   [0–8.4]* [0–7.9]* [0–7.9]* [1.1–16.3]
2004 Guinea, Dabola 1.0 0.9 0.9 0.9
   [0–5.3] [0–5.1] [0.1–6.5] [0.1–6.5]
2004 S Leone, Kailahun 27.0 15.4 19.0 20.5
   [16.6–39.6] [9.3–23.6] [12.3–28.8] [13.5–30.5]
2004 Uganda, Apac 24.5 15.0 15.7 15.9
   [16.2–34.4] [9.8–21.7] [10.7–22.7] [10.8–23.1]
2004 Uganda, Arua 28.7 19.9 20.0 20.0
   [20.4–38.2] [13.9–27.0] [14.5–27.2] [14.6–27.0]
2004 Uganda, Tororo 39.3 14.5 17.8 20.0
   [27.1–52.7] [9.5–20.9] [12.1–25.8] [13.6–28.9]
2005 Uganda, Tororo 13.9 5.5 5.4 5.9
   [6.9–24.1] [2.6–9.8] [2.9–9.8] [3.3–10.4]
  1. *one-sided 97.5% CIs