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Table 2 Association of serum IgG levels to recombinant domains of Pf EMP1 with clinical malaria in Chonyi, Kenya for the period October 2000 until March 2001

From: Acquisition of naturally occurring antibody responses to recombinant protein domains of Plasmodium falciparum erythrocyte membrane protein 1

Chonyi   Slide all n = 596
Antigen Odds Ratio p-value 95% C. I.
DBL1α 0.75 0.580 0.26 – 2.11
DBL2β 0.63 0.472 0.18 – 2.21
CIDR1α 0.71 0.365 0.33 – 1.50
DBL4γ 0.89 0.791 0.37 – 2.13
DBL5β 0.72 0.517 0.26 – 1.95
Chonyi   Slide positive n = 197
Antigen Odds Ratio p-value 95% C. I.
DBL1α 0.75 0.580 0.26 – 2.11
DBL2β 0.63 0.472 0.18 – 2.21
CIDR1α 0.71 0.365 0.33 – 1.50
DBL4γ 0.89 0.791 0.37 – 2.13
DBL5β 0.72 0.517 0.26 – 1.95
Chonyi   Slide negative n = 399
Antigen Odds Ratio p-value 95% C. I.
DBL1α 0.05 0.020 0.04 – 0.63
DBL2β 0.26 0.208 0.32 – 2.10
CIDR1α 0.72 0.553 0.25 – 2.10
DBL4γ 0.49 0.290 0.14 – 1.81
DBL5β 0.49 0.343 0.11 – 2.11
  1. 1Results from a multiple logistic regression giving the odds ratio for becoming a case of clinical malaria in the subsequent six months if scored as antibody positive against each domain in turn controlling for for age (categorized as a factor of six months duration) and exposure (estimated by responses to whole schizont extract). An individual was deemed antibody positive if the OD obtained was greater than the mean OD plus 3 standard deviations obtained from a panel of non-exposed donors.