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Table 5 IgG subclass levels separated by FcγRIIa R131H genotypes and alleles in the Fulani and Dogon ethnic groups

From: Differences in Fcgamma receptor IIa genotypes and IgG subclass pattern of anti-malarial antibodies between sympatric ethnic groups in Mali

 

Dogon

Fulani

 

no.

age

IgG1

IgG2

IgG3

IgG4

no.

age

IgG1

IgG2

IgG3

IgG4

H/H

24

15

15 ± 2.9

0.4 ± 5.6

4.5 ± 3.5

0.54 ± 2.0

39

15

34 ± 4.4

5.9 ± 11

6.3 ± 2.5

0.29 ± 7.8

H/R

69

16

17 ± 3.9

1.2 ± 6.7

3.8 ± 2.6

2.3 ± 2.3

68

23

38 ± 3.7

7.5 ± 9.1

12 ± 2.8

1.8 ± 2.6

R/R

64

20

24 ± 3.5

1.5 ± 8.1

6.2 ± 2.9

0.41 ± 2.9

36

21

24 ± 3.4

2.4 ± 9.8

9.5 ± 2.9

0.42 ± 2.3

p-value a

 

0.07

0.2

0.02

0.03

0.5

 

0.07

0.2

0.05

0.01

0.04

R-allele carriers

133

18

20 ± 3.7

1.3 ± 7.3

4.8 ± 2.8

0.43 ± 2.5

93

22

33 ± 3.6

5.0 ± 10

11 ± 2.8

0.5 ± 2.5

p-value b

 

0.3

0.4

0.007

0.8

0.2

 

0.03

0.08

0.1

0.009

0.4

H-allele carriers

104

22

17 ± 3.6

0.89 ± 6.7

3.9 ± 2.8

0.46 ± 2.3

107

20

37 ± 3.9

6.8 ± 9.5

9.4 ± 2.8

0.44 ± 4.4

p-value c

 

0.02

0.9

0.7

0.004

0.02

 

0.9

0.09

0.02

0.9

0.8

  1. The results are expressed in ELISA units and presented as geometric means ± SD.
  2. a Statistical analysis of differences in IgG subclass levels between the different genotypes tested with ANOVA
  3. b Statistical analysis of differences in IgG subclass levels between the R-allele carriers and HH homozygotes Mann-Whitney.
  4. c Statistical analysis of differences in IgG subclass levels between the H-allele carriers and RR homozygotes by Mann-Whitney.
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Malaria Journal

ISSN: 1475-2875

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