Interpeak latencies I–V, I–III, III–V. Mean interpeak latencies between Jewett waves I, III and V +/- 1 standard deviation (solid line: Quinine, dashed line: Atovaquone/proguanil, dotted line: Artemether/lumefantrine). Interpeak latencies in all groups are shorter on day 0, when patients have elevated body temperature. The difference in IPL I–III between the Artemether/lumefantrine group and the other two groups is limited to the right ear. No permanent drug-related prolongation of interpeak latencies occurs, as confirmed by multivariate analysis.