Skip to main content

Table 2 Median inhibitory concentrations of study drugs in P. falciparum field isolates of Gabona

From: Comprehensive study of proteasome inhibitors against Plasmodium falciparum laboratory strains and field isolates from Gabon

Drug

no.

IC50

IC90

IC99

Epoxomicin

22

8.50 (3.36 – 15.9)

12.4 (4.30 – 44.8)

20.5 (4.96 – 89.5)

MG132

22

38.2 (10.0 – 63.9)

99.5 (43.4 – 216)

206 (77.3 – 454)

Bortezomib

11

1452 (175 – 2477)

2500 (312 – 2871)

2911 (348 – 2990)

Lactacystin

11

588 (118 – 5318)

2015 (169 – 6289)

3318 (254 – 9278)

Artesunate

43

0.96 (0.20 – 5.95)

2.47 (0.33 – 29.9)

5.76 (0.57 – 49.1)

Chloroquineb

43

113 (12.4 – 332)

241 (20.1 – 737)

544 (40.2 – 967)

  1. a Results are shown in nM (median [range])
  2. b All isolates are beyond the threshold level of resistance (1 μM corresponds to 30 nM in our assay conditions)