Skip to main content

Table 3 Clinical and parasitological responses to treatment with artemether-lumefantrine by body weight group

From: Evaluation of the efficacy and safety of artemether-lumefantrine in the treatment of acute uncomplicated Plasmodium falciparum malaria in Nigerian infants and children

  Body weight group
Characteristic BWG1
5-<10 kg
BWG2
10-<15 kg
BWG3
15-<25 kg
Total
5-<25 kg
Cure rates ITT %(n/M)1 (uncorrected) N = 50 N = 37 N = 16 N = 103
   Day 7 98.0% (49/50) 97.3% (36/37) 100.0% (16/16) 98.1% (101/103)
   Day 14 96.0% (48/50) 94.6% (35/37) 93.8% (15/16) 95.1% (98/103)
   Day 28 92.0% (46/50) 89.2% (33/37) 93.8% (15/16) 91.3% (94/103)
   95% CI (80.8–97.8) (74.6–97.0) (69.8–99.8) (84.1–95.9)
Day 28 (PCR corrected) 96.0% (48/50) 94.6% (35/37) 93.8% (15/16) 95.1% (98/103)
   95% CI (86.3–99.5) (81.8–99.3) (69.8–99.8) (89.0–98.4)
Cure rate PP %(n/M)1 (uncorrected) N = 45 N = 34 N = 14 N = 93
   Day 7 100% (45/45) 100% (34/34) 100% (14/14) 100% (93/93)
   Day 14 100% (45/45) 100% (34/34) 100% (13/13) 100% (92/92)
   Day 28 95.6% (43/45) 94.1% (32/34) 100% (13/13) 95.7% (88/92)
   95% CI (84.9–99.5) (80.3 – 99.3) (-) (89.2 – 98.8)
PCT (h) ITT N = 50 N = 37 N = 16 N = 103
Mean ± SE 24.8 ± 1.3 26.2 ± 2.31 21.2 ± 4.33 24.9 ± 1.28
   Range 5.3 – 47.8 7.7 – 59.9 7.2 – 71.1 5.3–71.1
   Median 23.8 23.8 23.0 23.8
   95%CI2 (23.7–23.9) (23.1–35.3) (7.9–23.8) (23.7–23.8)
FCT (h) ITT) N = 50 N = 37 N = 16 N = 103
Mean ± SE 24.5 ± 3.81 17.6 ± 2.04 44.2 ± 19.98 26.1 ± 4.14
   Range 3.5 – 163.8 4.1 – 47.5 7.2–308.7 3.5–308.7
   Median 23.4 8.2 15.4 22.4
   (95% CI)2 (7.8–23.8) (7.8–23.4) (7.8–34.6) (7.9–23.5)
  1. 1In some instances N is different from M as M = number of patients who had the measurement at given time point
  2. 2The CI is provided for the median